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Anti-TrkA/B/C Antibody (9N825)
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产品编号 TMAC-04133
别名 neurotrophic tyrosine kinase, receptor, type 1
Anti-TrkA/B/C Antibody (9N825) 是一种 Rabbit 抗体，靶向 TrkA/B/C。Anti-TrkA/B/C Antibody (9N825) 可用于 WB,ICC,IHC。
Anti-TrkA/B/C Antibody (9N825)
Anti-TrkA/B/C Antibody (9N825)
还可以产品编号 TMAC-04133 别名 neurotrophic tyrosine kinase, receptor, type 1
Anti-TrkA/B/C Antibody (9N825) 是一种 Rabbit 抗体，靶向 TrkA/B/C。Anti-TrkA/B/C Antibody (9N825) 可用于 WB,ICC,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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| 产品描述 | Anti-TrkA/B/C Antibody (9N825) is a Rabbit antibody targeting TrkA/B/C. Anti-TrkA/B/C Antibody (9N825) can be used in WB,ICC,IHC. |
| 别名 | neurotrophic tyrosine kinase, receptor, type 1 |
| Ig Type | IgG |
| 克隆号 | 9N825 |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of TrkA+B+C on different lysates using anti-TrkA+B+C antibody at 1/1,000 dilution. Positive control: Lane 1: Rat brain, Lane 2: Mouse brain. 2. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-TrkA+B+C antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-TrkA+B+C antibody. Counter stained with hematoxylin. 4. ICC staining TrkA+B+C in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining TrkA+B+C in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-5000; IHC: 1:50-200; ICC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas. TrkB is overexpressed in tumors such as neuroblastoma, prostate adenocarcinoma and pancreatic ductal adenocarcinoma. In neuroblastomas overexpression of TrkB correlates with unfavorable disease outcome when autocrine loops signaling tumor survival are potentiated by additional overexpression of brain-derived neurotrophic factor (BDNF). An alternatively spliced truncated TrkB isoform lacking the kinase domain is overexpressed in Wilms?? tumors and this isoform may act as a dominant-negative to TrkB signaling. Altered TrkC expression and corresponding gene mutations are seen in various forms of cancer, with increased expression a positive prognostic indicator in patients with medulloblastoma. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| 分子量 | Theoretical: 140 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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