Name: Tanezumab
Brand: TargetMol
SKU: T78282
Price: 1730 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,730

现货

5 mg

¥ 4,350

现货

10 mg

¥ 6,150

现货

25 mg

¥ 9,120

现货

生物活性

产品描述	Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF (nerve growth factor). It inhibits the sensitisation and conduction of peripheral pain fibres by blocking the interaction between NGF and the p75 and TrkA receptors, thereby treating various acute and chronic pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.
体外活性	方法：为了评估 Tanezumab 对细胞迁移的影响，MiaPaCa-2 和 CFPAC-1 细胞经 100 ng/mL 药物处理，孵育 48 小时后进行细胞迁移实验。结果： Tanezumab 显著抑制了 MiaPaCa-2 和 CFPAC-1 细胞的迁移能力 [3]。
体内活性	方法：为了评估 Tanezumab 的体内抗肿瘤效果，在 MiaPaCa-2 异种移植瘤小鼠模型中，以 10 mg/kg 剂量每日皮下注射，连续给药 8 周。结果： Tanezumab 可降低肿瘤体积和神经侵犯直径，并改善后肢功能障碍 [3]。
别名	塔奈珠单抗
反应种属	Human
验证活性	Immobilized Human Beta-NGF Protein (TMPY-01010U) at 1 μg/mL (100 μL/well) can bind Tanezumab. The EC50 is 4.30 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG2 kappa
推荐同型对照	Human IgG2 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	145.43 kDa
CAS No.	880266-57-9

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Tanezumab