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15
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35880 | Renin Fluorogenic Substrate | ||
The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm. | |||
T38900 |
Renin FRET Substrate I
|
||
Renin FRET Substrate I is a specific compound that functions as a substrate for human renin. It is specifically designed to contain the exact cleavage site found in the N-terminal peptide of human angiotensinogen. | |||
TP2351 |
Renin inhibitory peptide
Pro-his-pro-phe-his-phe-phe-val-tyr-lys |
||
Renin inhibitory peptide is an analog of angiotensinogen. | |||
TP2351L |
Renin inhibitory peptide, statine
SCRIP,Iva-his-pro-phe-his-sta-leu-phe-NH2 |
||
Renin inhibitory peptide, statine is a effective, specific statine-containing renin inhibitor. | |||
T80244 |
Renin inhibitor peptide,rat
|
||
Renin inhibitorpeptide,rat 是一种特定的大鼠肾素抑制剂,具有生物活性的肽。 | |||
T76443 |
Renin substrate 1
|
||
Reninsubstrate 1 是一种对酶具有高亲和力的肾素 (renin) 底物。 | |||
T62138 | Renin inhibitor-1 | ||
Renin inhibitor-1 (compound 26) 是一种有效的、口服具有活力的肾素抑制剂,能够作用于 rh-renin (IC50: 0.9 nM) 和 hPRA (IC50: 1.8 nM)。Renin inhibitor-1 具有抗高血压作用,具有潜力进行高血压和心血管/肾脏疾病的研究。 | |||
T26127 |
R-PEP 27
Renin inhibitory peptide, R-pep-27,Pro-his-pro-phe-his-statine-ile-phe-NH2 |
||
R-PEP 27 is an inhibitor of potent renin, decreased plasma angiotensin II, and blood pressure in normal volunteers. | |||
TP1929L1 |
Saralasin acetate(34273-10-4 free base)
|
RAAS | Endocrinology/Hormones |
Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。 | |||
T7714 |
Temocapil
|
Tyrosinase | Proteases/Proteasome |
Temocapil 是一种酪氨酸激酶抑制剂。 | |||
T1520 |
Aliskiren hemifumarate
阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂,IC50为1.5 nM,具有抗高血压活性。 | |||
T3064 |
VTP-27999
VTP27999 |
RAAS | Endocrinology/Hormones |
VTP-27999是烷基胺肾素抑制剂,它已用于研究肾功能基础科学的试验。 | |||
T7668 |
VTP-27999 TFA
N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯 2,2,2-三氟乙酸盐 |
RAAS | Endocrinology/Hormones |
VTP-27999 TFA 是烷基胺肾素抑制剂(IC50:0.47 nM)。 | |||
T6666 |
Sevelamer Carbonate
|
Others | Others |
Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂,能有效降低体内血清磷水平,但对体内血清钙、氯水平影响极小,可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。 | |||
T6698 |
Temocapril hydrochloride
CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利 |
RAAS | Endocrinology/Hormones |
Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。 | |||
T37683 |
3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine |
Others | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。 | |||
T71760 |
4-Chlorokynurenine
|
||
4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor. | |||
T70549 |
Kadsurenin L
|
||
Kadsurenin L is a neolignan originally isolated from Piper kadsura. It has a role as a platelet-activating factor receptor antagonist and a plant metabolite. | |||
T125390 |
Glisoprenin D
|
||
Glisoprenin D 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125390,CAS号为 205594-89-4。 | |||
T124831 |
Scillarenin
|
||
Scillarenin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124831,CAS号为 465-22-5。 | |||
T72430 |
L-Kynurenine sulfate
|
||
L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂,可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。 | |||
T3011L |
Kynurenine sulfate monohydrate
L-Kynurenine sulfate monohydrate |
||
Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma | |||
T34194 | Puntarenine | ||
Puntarenine is an alkaloid of the isohomoprotoberberine family that has shown marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae. | |||
T32361 | Karenin | ||
Karenin is a bioactive chemical. | |||
T4313 |
Tinoridine hydrochloride
盐酸替诺立定,Nonflamin,Y-3642 hydrochloride |
COX; Glutathione Peroxidase | Immunology/Inflammation; Metabolism; Neuroscience |
Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药,具有显著的自由基清除和抗过氧化物特性。 | |||
T28950 |
Terlakiren
CP 80794,CP-80,794 |
RAAS | Endocrinology/Hormones |
Terlakiren (CP-80,794) 是一种具有口服活性和高效性的肾素 (Renin) 抑制剂,抑制人肾素的效能,可用于研究高血压类的神经系统疾病。 | |||
T3695 |
Pepstatin
抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C |
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂,可抑制 HIV 蛋白酶的活性。 | |||
TP1842L |
Angiotensinogen (1-14), human acetate
|
Endogenous Metabolite | Metabolism |
Angiotensinogen (1-14), human acetate 是血管紧张素原的片段,它是肾素-血管紧张素系统的被动底物。 | |||
T2639 |
LY2811376
|
Beta Amyloid; Beta-Secretase; BACE | Neuroscience |
LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂,IC50=239 nM-249 nM,能够降低 Aβ 蛋白的分泌,EC50=300 nM。 | |||
TP1295 |
Angiotensin I (human, mouse, rat)
Angiotensin 1 Human,血管紧张素 1 (人) |
Others | Others |
Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质,在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。 | |||
T37496L |
Alamandine TFA
|
RAAS | Endocrinology/Hormones |
Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员,是一种血管活性肽,是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。 | |||
T22574L |
Angiotensin 1/2 (5-7) acetate
|
RAAS | Endocrinology/Hormones |
Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽,是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原,一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。 | |||
T14123 |
ACT 178882
|
RAAS | Endocrinology/Hormones |
ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM). | |||
T19187 |
Aliskiren D6 hemifumarate
CGP 60536 D6 hemifumarate,SPP 100 D6 hemifumarate,CGP60536B D6 hemifumarate |
RAAS | Endocrinology/Hormones |
Aliskiren (CGP 60536) D6 hemifumarate is a deuterium-labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM). | |||
T26439 |
A 74273
A-74273,A74273 |
||
A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition. | |||
T26431 |
A 65317
A-65317,A65317 |
||
A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system. | |||
T28328 |
PD 132002
PD-132002,PD132002 |
||
PD 132002 is a renin inhibitor. | |||
T27306 |
Fasidotril
BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137 |
||
Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension. | |||
T30829 |
Cgp 38560
Cgp38560,Cgp-38560 |
||
CGP 38560 is a potent renin inhibitor. | |||
T25369 |
Emd 52297
Emd-52297,Emd52297 |
||
Emd 52297 is an inhibitor of renin. | |||
T25233 |
CH 66
CH66,Piv-his-pro-phe-leu(OH)leu-tyr-tyr-ser-NH2,CH-66 |
||
CH 66 is an inhibitor of renin. | |||
T25370 |
Emd 55068
Emd-55068,Emd55068 |
||
Emd 55068 is a synthetic antagonist of renin. | |||
T25386 |
ES 6864
ES-6864,ES6864 |
||
ES 6864 is an orally active inhibitor of renin. | |||
T71318 | H 218-54 | ||
H 218-54 is a renin inhibitor. | |||
T30921 |
CI 992
CI-992,CI992 |
||
CI 992 is a novel potent inhibitor of primate renin. | |||
T25368 |
Emd 51921
Emd51921,Emd-51921,Emd-51,921,Emd 51,921,Emd 51 921 |
||
Emd 51921 is a linear peptide renin inhibitor. | |||
T26170 |
S 863390
S863390,S-86,3390 S86,3390,S 86,3390,S-863390 |
||
S 863390 is a renin inhibitor. | |||
T25387 |
ES 8891
ES-8891,ES8891 |
||
ES 8891 is an inhibitor of renin. | |||
T24284 |
L 363564
L-363,564,L-363564,L363,564,L363564,L 363,564 |
||
L 363564 is a kidney renin inhibitor. | |||
T31033 |
CP 81282
CP81282,CP-81,282,CP-81282 |
||
CP 81282 inhibits human renin and endothiapepsin. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0290 |
Araloside A
Chikusetsusaponin IV,竹节参皂苷IV |
RAAS; Fas/FasL | Apoptosis; Endocrinology/Hormones |
Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素renin 具有低抑制活性(IC50:77.4 μM)。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TN6778 |
Umbelliprenin
伞形花醚,7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin |
IL Receptor | Immunology/Inflammation |
Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) 可减轻神经性疼痛,并降低血清 IL-6 水平和氧化应激。 | |||
T79948 |
Kadsurenin B
|
||
Kadsurenin B为PAF(platelet-activating factor)拮抗剂,展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力,包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。 | |||
TN4302 |
Isokadsurenin D
|
Others | Others |
Isokadsurenin D是一种天然产物,属于五味子科南五味子属,其产品编号为 TN4302,CAS号为 147976-35-0。Isokadsurenin D可用作对照参考。 | |||
T2S1727 |
Lycorenine
|
Antifection | Microbiology/Virology |
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph | |||
TN3054 | 4-O-Demethylisokadsurenin D | Others | Others |
4-O-Demethylisokadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3054,CAS号为 89104-59-6。 | |||
T3S0804 |
Worenine
甲基黄连碱,Worenin |
Others | Others |
Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢,氢化,羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。 | |||
TN4365 |
Kadsurenin D
|
Others | Others |
Kadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4365,CAS号为 140669-89-2。 | |||
TN3055 |
4-O-Demethylkadsurenin D
|
Others | Others |
4-O-Demethylkadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3055,CAS号为 127179-70-8。 | |||
T81994 |
Kadsurenin A
|
||
Kadsurenin A是一种生物活性木脂素,具有潜在的药用价值。 | |||
T0522 |
Diammonium Glycyrrhizinate
甘草酸二铵,Glycyrrhizin |
Dehydrogenase | Metabolism |
Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物,有抗炎作用。 | |||
T19186 |
Aldosterone
|
Others | Others |
Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex. | |||
T38649 | Lyciumin A | ||
Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00908 |
Renin Protein, Human, Recombinant (His)
REN,renin,FLJ10761,HNFJ2 |
Human | HEK293 Cells |
Renin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is P00797-1. | |||
TMPY-05808 |
Renin Protein, Human, Recombinant (R66K, His)
REN,FLJ10761,renin,HNFJ2 |
Human | HEK293 Cells |
Renin Protein, Human, Recombinant (R66K, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.74 kDa and the accession number is P00797-1. | |||
TMPY-01231 |
Renin Protein, Mouse, Recombinant (His)
Ren-A,Ren-1,Ren1,Ren1d,Ren,D19352,Rnr,Ren1c,renin,R... |
Mouse | HEK293 Cells |
Renin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.2 kDa and the accession number is P06281. | |||
TMPH-02881 |
Renin-2 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood. Renin-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number ... | |||
TMPH-02023 |
Renin receptor Protein, Human, Recombinant (His)
|
Human | E. coli |
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-02418 |
kynureninase/KYNU Protein, Mouse, Recombinant (His)
kynureninase,4432411A05Rik |
Mouse | Baculovirus Insect Cells |
kynureninase/KYNU Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9CXF0. | |||
TMPY-02479 |
kynureninase/KYNU Protein, Human, Recombinant (His)
KYNUU,kynureninase |
Human | Baculovirus Insect Cells |
kynureninase/KYNU Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.80 kDa and the accession number is Q16719. | |||
TMPH-03351 |
KLKB1 Protein, Rat, Recombinant (E. coli, His)
|
Rat | E. coli |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.8 kDa and the accession number is P14272. | |||
TMPH-03352 |
KLKB1 Protein, Rat, Recombinant (His)
|
Rat | P. pastoris (Yeast) |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.8 kDa and the accession number is P14272. | |||
TMPY-01635 |
PCSK1 Protein, Human, Recombinant (His)
proprotein convertase subtilisin/kexin type 1,SPC3,PC1,BMIQ1... |
Human | HEK293 Cells |
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav... |