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Anti-Renin Antibody (5W254) 是一种 Mouse 抗体,靶向 Renin。Anti-Renin Antibody (5W254) 可用于 ELISA,IHC-P。
Anti-Renin Antibody (5W254) 是一种 Mouse 抗体,靶向 Renin。Anti-Renin Antibody (5W254) 可用于 ELISA,IHC-P。
产品描述 | Anti-Renin Antibody (5W254) is a Mouse antibody targeting Renin. Anti-Renin Antibody (5W254) can be used in ELISA,IHC-P. |
Ig Type | Monoclonal Mouse IgG2b |
克隆号 | 5W254 |
交叉反应 | Human |
验证活性 | Immunochemical staining of human RENIN in human kidney (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
应用 | ELISA,IHC-P |
推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Renin (rh Renin; TMPY-00908; NP_000528.1; Met 1-Arg 406). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression. |
偶联 | Unconjugated |
免疫原 | Recombinant Human Renin protein (TMPY-00908) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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