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Anti-Renin Antibody (5W254)

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产品编号 TMAY-01382

Anti-Renin Antibody (5W254) 是一种 Mouse 抗体,靶向 Renin。Anti-Renin Antibody (5W254) 可用于 ELISA,IHC-P。

Anti-Renin Antibody (5W254)

Anti-Renin Antibody (5W254)

Rating icon 还可以
产品编号 TMAY-01382

Anti-Renin Antibody (5W254) 是一种 Mouse 抗体,靶向 Renin。Anti-Renin Antibody (5W254) 可用于 ELISA,IHC-P。

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产品介绍

生物活性
产品描述
Anti-Renin Antibody (5W254) is a Mouse antibody targeting Renin. Anti-Renin Antibody (5W254) can be used in ELISA,IHC-P.
Ig Type
Monoclonal Mouse IgG2b
克隆号
5W254
交叉反应
Human
验证活性
Immunochemical staining of human RENIN in human kidney (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
应用
ELISA,IHC-P
推荐剂量
ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Renin (rh Renin; TMPY-00908; NP_000528.1; Met 1-Arg 406). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Human Renin protein (TMPY-00908)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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