mutase

L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸，是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂，用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂，Ki 为 980 nM。

PGMI-004A 是磷酸甘油酸变位酶 1 抑制剂，IC50=13.1 μM。

HKB99 是磷酸甘油酸突变酶 1(PGAM1) 的变构抑制剂，抑制非小细胞肺癌的生长和转移。HKB99 与EGFR抑制剂具有协同作用，可协助EGFR抑制剂杀瘤。HKB99 促进氧化应激，可诱导多种信号通路发生变化。HKB99 可用于研究代谢相关疾病。

LFHP-1c 是一种新型 PGAM5 抑制剂，在缺血性脑卒中模型中显示出神经保护活性，可防止大鼠短暂性大脑中动脉闭塞（tMCAO）后的BBB破坏。LFHP-1c 可用于研究脑缺血性中风。

Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。

Superoxide dismutase（SOD，超氧化物歧化酶）是一种交替催化超氧化物阴离子自由基（O2-)歧化分解为O2和H2O2的酶，是一种重要的抗氧化防御机制，能有效地减少促炎细胞因子和抑制中性粒细胞向组织损伤部位的浸润。

Mn Superoxide dismutase (Mn SOD)，这种抗氧化酶主要分布在线粒体内，它能将超氧化物阴离子(O2·-) 催化转化为氧气 (O2) 与过氧化氢 (H2O2)。此酶通过防止氧化损伤来保护细胞，对于移植排斥、神经退行性疾病、心血管疾病及癌症具有重要影响。

Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。

Adenosylcobalamin (AdoCbl) 是一种 Vitamin B12的特性形式，其中 Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。

MJE3 is an inhibitor of phosphoglycerate mutase-1 (PGAM1), it displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis.

PGAM1-IN-1 是一种有效的磷酸甘油酸变位酶 1 (PGAM1) 抑制剂(IC50=6.4 μM)。

PGAM1-IN-2 是一种有效的磷酸甘油酸变位酶 1 (PGAM1) 抑制剂 (IC50=2.1 μM)。

Enasidenib mesylate (AG-221 mesylate) 是一种具有有效性和选择性的 IDH2 突变酶抑制剂，可促进白血病成髓细胞的分化，可用于治疗急性髓系白血病。

1-Deaza-fad also known as Deazafad. 1-deazaFAD has comparable activity in the mutase reconstituted.

Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J. Bacteriol.197(4)727-735(2015) 2.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011)

Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011) 2.Tabita, F.R.The hydroxypropionate pathway of CO2 fixation: Fait accompliProc. Natl. Acad. Sci. U.S.A.106(50)21015-21016(2009) 3.Medicine, I.o.Vitamin B12Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline306-356(1998) 4.Cardinale, G.J., Carty, T.J., and Abeles, R.H.Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B12 deficiency, on fatty acid synthesisJ. Biol. Chem.245(15)3771-3775(1970)

UGM-IN-3 (compound 10a) 是一种 UDP-吡喃半乳糖变位酶 (UGM) 抑制剂，Kd 为 66 μM。UGM-IN-3 抑制结核分枝杆菌的生长，MIC 值为 6.2 μg mL。

Methylmalonyl-CoA tetralithium 是由单链脂肪酸、胆固醇及部分氨基酸（如缬氨酸、异亮氨酸、蛋氨酸、苏氨酸）分解而成的产物。该化合物通过MCM(Methylmalonyl-CoA mutase)和其辅酶维生素 B12 的催化作用转化为琥珀酰辅酶 A。