Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Neboglamine (CR-2249, XY-2401) hydrochloride 是NMDA 受体甘氨酸位点的正向调节剂,具有口服活性,可用于研究精神分裂症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,580 | 现货 | ||
5 mg | ¥ 3,990 | 现货 | ||
10 mg | ¥ 5,180 | 现货 | ||
25 mg | ¥ 7,790 | 现货 | ||
50 mg | ¥ 9,870 | 现货 |
产品描述 | Neboglamine (CR-2249, XY-2401) hydrochloride is a positive modulator of NMDA receptor glycine site with orally active that can be used in the research of schizophrenia [1]. |
体内活性 | Neboglamine hydrochloride (s.c. or p.o., 0.3-30 mg/kg) can regulate neuronal activity in brain regions and inhibit PCP-induced hypermobility in rats [1]. Animal Model: Male Wistar rats [1] Dosage: 20 mg/kg Administration: Subcutaneous injection Result: Increased neuronal activity in brain regions, prefrontal cortex (PFCX) from 38.5 to 121.3, nucleus accumbens (NAc) from 14.5 to 69.1 and lateral septal nucleus (LSN) from 16.2 to 73.1 but no effect on dorsolateral striatum (DL-STR) compared to the control group. Significantly inhibited phencyclidine-induced hypermobility. Animal Model: Male Wistar rats [1] Dosage: 0.3 mg/kg, 3 mg/kg, 30 mg/kg Administration: Oral administration Result: Reduced frequency of PCP-induced hypermobility and stereotyped behaviour in a dose-dependent manner and the dose inhibited stereotyped behaviour (0.3 mg/kg) was lower than the dose inhibited motor activity (3 mg/kg). |
分子量 | 292.8 |
分子式 | C13H25ClN2O3 |
CAS No. | 2759182-59-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Neboglamine hydrochloride 2759182-59-5 Inhibitor inhibitor inhibit