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抑制剂&激动剂
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TargetMol产品目录中 "phospholipase c"的结果
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phospholipase c

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  • 抑制剂&激动剂
    45
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    17
    TargetMol | Recombinant_Protein
  • 多肽产品
    2
    TargetMol | Peptide_Products
  • 天然产物
    6
    TargetMol | Natural_Products
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    4
    TargetMol | Antibody_Products
  • 分子与细胞研究
    4
    TargetMol | Inhibitors_Agonists
  • Enprofylline
    恩丙茶碱, Enprofyllinum, Enprofilina, 3-propylxanthine, 3-n-Propylxanthine
    T2138941078-02-8
    Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ,也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。
    • ¥ 278
    In stock
    规格
    数量
  • Vinaxanthone
    紫黄褐酮, SM-345431
    T70955133293-89-7In house
    Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物,是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂,抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性,阻止细胞内脂肪酸合成,抑制金黄色葡萄球菌的生长。
    • ¥ 3270
    In stock
    规格
    数量
  • Edelfosine
    T2275977286-66-9
    inhibits phosphatidylinositol phospholipase C
    • ¥ 10600
    6-8周
    规格
    数量
  • U-73343
    U 73343
    TQ0159142878-12-4
    U-73343 是一种 U-73122 的无活性类似物,能够剂量依赖性的抑制酸分泌,可作为 U-73122 的阴性对照。其中 U 73122 是一种有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂,对磷脂酶 C 的 IC50值约为 1-2.1 µM。
    • ¥ 373
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Protein kinase inhibitor H-7 dihydrochloride
    H-7 dihydrochloride
    T22831108930-17-2
    Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C(PKC)抑制剂。Protein kinase inhibitor H-7 dihydrochloride(100 μM)显著抑制 TPA (皮肤肿瘤启动子,12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶),抑制 PMA 诱导的混杂细胞溶解活性。
    • ¥ 113
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • 3-Nitrocoumarin
    3-硝基香豆素, 3-nitrochromen-2-one
    T1011528448-04-6
    3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。
    • ¥ 233
    In stock
    规格
    数量
  • Compound 48/80 trihydrochloride
    C48 80 trihydrochloride
    T13623848035-21-2
    Compound 48 80 trihydrochloride (C48 80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48 80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48 80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。
    • ¥ 148
    5日内发货
    规格
    数量
  • CCT129957
    T14903883098-58-6
    CCT129957 是一种新型有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 约为 3 μM,GC50 为 15 μM。CCT129957 具有抗癌活性,在鳞状细胞中抑制 Ca2+ 的释放。
    • ¥ 445
    In stock
    规格
    数量
  • D609
    T1504483373-60-8
    D609 (Tricyclodecan-9-yl-Xanthogenate) 具有广泛的生物活性,包括抗氧化、抗凋亡、抗胆碱能、抗肿瘤、抗炎、抗病毒、抗增殖和神经保护活性。D609 通过引起磷脂酰胆碱 (PC) 特异性磷脂酶 C (PC-PLC) 和鞘磷脂合酶 (SMS) 的竞争性抑制来发挥作用。
    • ¥ 198
    In stock
    规格
    数量
  • SPK-601
    LMV-601
    T169201096687-52-3
    SPK-601 is an inhibitor of phosphatidylcholine-specific phospholipase C.
    • ¥ 1050
    5日内发货
    规格
    数量
  • GK241
    T2005861899930-93-8
    GK241 (compound 31a-c) 为一种2-氧代酰胺衍生的化学物质,展现了对人类与小鼠的IIA组分泌型磷脂酶A2(GIIA sPLA2)具有显著的抑制作用(IC50为143 nM与68 nM),其抑制机制已通过分子动力学模拟得到探讨。
    • ¥ 10600
    4-6周
    规格
    数量
  • Lumi-PI
    T32950152305-53-8
    Lumi-PI is used as a chemiluminescent substrate for detecting phosphatidylinositol-specific phospholipase C.
    • ¥ 10600
    待询
    规格
    数量
  • D-myo-Inositol-1,4,5-triphosphate trisodium
    Ins(1,4,5)-P3 trisodium, Ins(1,4,5)P3, Inositol 1,4,5-trisphosphate trisodium, D-肌醇-1,4,5-三磷酸钠盐, D-myo-Inositol-1,4,5-triphosphate (sodium salt)
    T35935141611-10-1
    D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) 是由磷脂酶 C 介导的磷脂酰肌醇-4,5-二磷酸酯水解在细胞中产生的第二信使。D-myo-Inositol-1,4,5-triphosphate (sodium salt)与 Ins(1,4,5)P3受体结合,会导致钙通道的打开和细胞内钙的增加。
    • 待估
    35日内发货
    规格
    数量
  • D-myo-Inositol-1,4,6-triphosphate (sodium salt)
    T35936157380-18-2
    D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.
    • ¥ 5301
    待询
    规格
    数量
  • D-myo-Inositol-4-phosphate (ammonium salt)
    T35938142760-33-6
    D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.
    • ¥ 11942
    待询
    规格
    数量
  • PtdIns-(1,2-dioctanoyl) (sodium salt)
    T36937899827-36-2
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, compared to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
    • 待估
    35日内发货
    规格
    数量
  • PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
    PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
    T36939799268-62-5
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.
    • 待估
    35日内发货
    规格
    数量
  • PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
    PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
    T370281628353-02-5
    The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .
    • 待估
    35日内发货
    规格
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  • PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
    PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
    T370301246303-11-6
    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
    • 待估
    35日内发货
    规格
    数量
  • Tetranactin
    T3705233956-61-5
    Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-dependently increases the mortality of adult C. chinensis weevils up to 100% and has mitogenic activity against T. telarius when sprayed onto plants with an LC50 value of 9.2 μg/ml. It reduces IL-1β- and cAMP-induced secretion of phospholipase A2 (PLA2) from rat mesangial cells (IC50s = 43 and 33 nM, respectively). Tetranactin (50 ng/ml) suppresses the proliferation of human T lymphocytes induced by allogeneic cells and IL-2 and supresses the generation of cytotoxic T lymphocytes in mixed lymphocyte cultures. In vivo, tetranactin (10 mg/animal per day) completely inhibits the formation of experimental autoimmune uveoretinitis (EAU) in rats.
    • ¥ 3410
    35日内发货
    规格
    数量
  • D-myo-Inositol-1,2-diphosphate (sodium salt)
    T37057208584-51-4
    Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2)P2 (tested as the D L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.
    • 待估
    35日内发货
    规格
    数量
  • D-myo-Inositol-1,3-diphosphate (sodium salt)
    T37060208584-52-5
    D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,3)P2 can be dephosphorylated to Ins(1)P by inositol polyphosphate 3-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.
    • 待估
    35日内发货
    规格
    数量
  • 1,2-Dioctanoyl PC
    T3712319191-91-4
    Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom.
    • 待估
    35日内发货
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  • p-Nitrophenylphosphorylcholine
    T3743421064-69-7
    p-Nitrophenylphosphorylcholine is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
    • 待估
    35日内发货
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