Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tucatinib (ONT-380) 是可口服的选择性HER2抑制剂,IC50为8 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 293 | 现货 | ||
5 mg | ¥ 463 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,280 | 现货 | ||
50 mg | ¥ 1,980 | 现货 | ||
100 mg | ¥ 3,630 | 现货 | ||
500 mg | ¥ 7,880 | 现货 | ||
1 g | ¥ 10,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 659 | 现货 |
产品描述 | Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM). |
靶点活性 | ErbB2:8 nM |
体外活性 | Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. |
体内活性 | In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1]. |
别名 | ARRY-380, Irbinitinib, ONT-380 |
分子量 | 480.52 |
分子式 | C26H24N8O2 |
CAS No. | 937263-43-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 87 mg/mL(181.1 mM)
Ethanol: 15 mg/mL (31.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.0811 mL | 10.4054 mL | 20.8108 mL | 52.027 mL |
5 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4054 mL | |
10 mM | 0.2081 mL | 1.0405 mL | 2.0811 mL | 5.2027 mL | |
20 mM | 0.1041 mL | 0.5203 mL | 1.0405 mL | 2.6013 mL | |
DMSO | 50 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL |
100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tucatinib 937263-43-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER ARRY-380 Irbinitinib ONT 380 inhibit ErbB-1 HER1 ARRY 380 ARRY380 ONT-380 Epidermal growth factor receptor ONT380 Inhibitor inhibitor