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Hydroxyurea

Hydroxyurea

产品编号 T0676   CAS 127-07-1
别名: nci-c04831, 羟基脲, nsc32065, Hydroxycarbamide

Hydroxyurea 是一种抗肿瘤剂,通过抑制核糖核苷二磷酸还原酶来抑制 DNA 合成。

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Hydroxyurea, CAS 127-07-1
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产品目录号及名称: Hydroxyurea (T0676)
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纯度: 99.87%
纯度: 99.85%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
体外活性 hydroxyurea can inhibit HIV-1 replication. In vitro experiments have shown that the 90% inhibitory concentration (IC90) of hydroxyurea for laboratory strains of HIV-1 in activated PBMC is 0.4 mM. Hydroxyurea was also found to be synergistic with the nucleoside reverse transcriptase inhibitor didanosine and to inhibit HIV-1 replication in activated PBMC; this inhibition may be due to a reduction in deoxynucleoside triphosphate pool sizes. Hydroxyurea has been shown to sensitize didanosine-resistant mutants[1][2].hydroxyurea has demonstrated activity in the treatment of sickle cell anemia by increasing the production of fetal hemoglobin, which reduces hemolysis in patients with this disease. Hydroxyurea exerts its cytostatic effect through inhibition of ribonucleotide reductase—the rate-limiting enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. As a result, cellular division is arrested in the S phase[1].
体内活性 Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50 mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[5].
细胞实验 Erythroid cells obtained from peripheral blood of the same patients(Thirteen β-Thal/HbE patients are treated with hydroxyurea orally for 2 years at a starting dose of 5 mg/kg/day for 5 days/week with escalation to a maximum of 10 mg/kg/day) 1 year after they had stopped hydroxyurea treatment are treated with hydroxyurea in vitro.Treatment of cells performs in primary culture with 30 μM hydroxyurea for 96 hours.(Only for Reference)
别名 nci-c04831, 羟基脲, nsc32065, Hydroxycarbamide
分子量 76.06
分子式 CH4N2O2
CAS No. 127-07-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 50 mg/mL (657.38 mM)

H2O: 55 mg/mL (723.11 mM)

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Lori F, et al. Clin Infect Dis. 2000, 30 Suppl 2:S193-7. 2. Zala C, et al. Clin Infect Dis. 2000, Suppl 2:S143-50. 3. Watanapokasin Y, et al. Exp Hematol. 2005, 33(12):1486-92. 4. Boucher PD, et al. Gene Ther. 2002, 9(15):1023-30. 5. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603.

文献引用

1. Zhu H, Rao Z, Yuan S, et al. One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin. European Journal of Pharmacology. 2021: 174366.
TD52 (±)-α-Bisabolol AZD5582 Salinomycin sodium salt Ecdysone BS-181 SCR7 EPZ004777 hydrochloride

相关化合物库

该产品包含在如下化合物库中:
自噬库 抗癌化合物库 儿童药物库 DNA 损伤和修复分子库 已知活性化合物库 细胞凋亡化合物库 化疗药物库 抗衰老化合物库 抗癌药物库 免疫/炎症分子化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
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计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Hydroxyurea 127-07-1 Apoptosis Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HIV Protease DNA/RNA Synthesis Inhibitor Human immunodeficiency virus nci-c04831 inhibit 羟基脲 HIV nsc32065 Hydroxycarbamide inhibitor

 

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