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AMG131

Name: AMG131
Brand: TargetMol
SKU: T8780
Price: 323 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.37%

货号 T8780Cas号 315224-26-1

别名 INT-131, CHS 131, AMG-131

AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。

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AMG131

一键复制产品信息

很棒

纯度: 99.37%

货号 T8780 别名 INT-131, CHS 131, AMG-131Cas号 315224-26-1

AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。

规格	价格	库存
1 mg	¥ 323	现货
5 mg	¥ 745	现货
10 mg	¥ 1,230	现货
25 mg	¥ 2,230	现货
50 mg	¥ 3,360	现货
100 mg	¥ 4,970	现货
500 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 843	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

AMG131 AI Summary

AMG131 exhibits a range of bioactivities related to its antidiabetic effects and modulation of PPARgamma. It displaces rosiglitazone from PPARgamma LBD with potent Ki values between 10.0 nM and 17.0 nM. This compound decreases blood glucose levels in Zucker fatty rats (ED30 of 0.3 mg/kg/day) and KKAy diabetic mouse models (60% reduction), while also reducing insulin levels in the latter at a dose of 30 mg/kg/day. In terms of weight gain, it increases body weight by 170.0% in KKAy mice at 30 mg/kg/day and by 42.0% in Zucker fatty rats at 3 mg/kg/day. Its efficacy relative to rosiglitazone varies, showing 24.0% to 40.0% in transactivation assays and it also has an agonist activity with EC50 values ranging from 4.0 nM to 500.0 nM, depending on the assay and cell type. Pharmacokinetic studies indicate dose-dependent AUC and Cmax in Sprague-Dawley rats. The compound also exhibits a moderate inhibitory effect on CYP3A4 with an IC50 of 25000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)
别名	INT-131, CHS 131, AMG-131

化学信息

分子量	514.21
分子式	C₂₁H₁₂Cl₄N₂O₃S
CAS No.	315224-26-1
Smiles	Clc1ccc(c(Cl)c1)S(=O)(=O)Nc1cc(Cl)c(Oc2cnc3ccccc3c2)c(Cl)c1
密度	1.585 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (53.48 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9447 mL	9.7237 mL	19.4473 mL	97.2365 mL
5 mM	0.3889 mL	1.9447 mL	3.8895 mL	19.4473 mL
10 mM	0.1945 mL	0.9724 mL	1.9447 mL	9.7237 mL
20 mM	0.0972 mL	0.4862 mL	0.9724 mL	4.8618 mL
50 mM	0.0389 mL	0.1945 mL	0.3889 mL	1.9447 mL