trap-5

H-Ser-Phe-Leu-Leu-Arg-OH 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5)，用于研究冠心病 (CHD)。

TRAP-5 amide为蛋白酶激活受体1（PAR1）特异性的激动剂肽。

Carboxy-pyridostatin是经典G-四链体配体pyridostatin的羧基修饰衍生物，能够选择性结合并稳定G-quadruplex结构，从而影响端粒及基因调控相关区域的DNA构象。Carboxy-pyridostatin对DNA G4s上的RNA具有高度分子特异性，并可降低ATF-5蛋白。Carboxypyridostatin可抑制细胞增殖并阻碍应激颗粒(SG)的形成。

Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline. It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α-thrombin. TRAP-14 also induces contraction of isolated rat aortic rings and increases endothelin-1 (ET-1) levels in a dose-dependent manner, an effect that is reversed by the ETA antagonist BQ-123 and the nitric oxide synthase (NOS) inhibitor L-NNA .