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68

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37427	(2R/S)-6-PNG 6-Prenylnaringenin,(±)-6-Prenylnaringenin	Calcium Channel; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	(2R/S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂，具有抗癌抗肿瘤活性，可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。
T10165L	5-A-RU hydrochloride 5-Amino-6-(D-ribitylamino)uracil hydrochloride	Others	Others
	5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) 是细菌核黄素的中间体，可激活粘膜相关不变 T 细胞（MAIT）。5-A-RU 可用于研究乳腺癌和前列腺癌。
T11447	GNF4877	GSK-3; DYRK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	GNF4877 是一种 DYRK1A (IC50:6 nM) 和 GSK3β (IC50:16 nM) 抑制剂。它导致激活 T 细胞核因子核输出的阻断和 β 细胞增殖细胞增加。
T21618L	Myelin Basic Protein (87-99) Acetate Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)	Others	Others
	Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) 是一种致脑炎肽，可诱导碱性蛋白特异性 T 细胞增殖。它导致外周血单核细胞中的 Th1 极化，这与多发性硬化症 (MS) 有牵连。
TP1606L	NLS PKKKRKV acetate(95088-49-6 free base)	Others	Others
	NLS PKKKRKV acetate(95088-49-6 free base) 是从大猿病毒40肿瘤抗原（SV40大T 抗原）衍生的肽，是基因转移研究领域中增强核入口的一种方法。
T12079	ML604440	Proteasome	Proteases/Proteasome; Ubiquitination
	ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂，能够破坏 MHC I 类细胞表面表达，IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。
TP1516L	C-Reactive Protein (CRP) 77-82 acetate C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)	Others	Others
	C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物，是心血管风险标志物，可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状（环状）五聚体蛋白，存在于血浆中，其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白，在巨噬细胞和 T 细胞分泌 IL-6 后会增加。
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T61968	PD-1/PD-L1-IN 6
	PD-1/PD-L1-IN 6 (compound A13) 是有效的PD-1/PD-L1相互作用抑制剂（IC50为 132.8 nM）。PD-1/PD-L1-IN 6 显示出显著的免疫调节活性。在 Hep3B/OS-8/hPD-L1 与 CD3 T 细胞共培养模型中，PD-1/PD-L1-IN 6显著提高干扰素 -γ 分泌，且无明显毒性作用。在 T 细胞-肿瘤共培养模型中，PD-1/PD-L1-IN 6恢复免疫应答。
T67238	Acetonitrilebis[2-diphenylphosphino-6-t-butylpyridine]cyclopentadienylruthenium(II) hexafluorophosphate
	Acetonitrilebis[2-diphenylphosphino-6-t-butylpyridine]cyclopentadienylruthenium(II) hexafluorophosphate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67238。
T10165	5-A-RU 5-Amino-6-(D-ribitylamino)uracil	Others	Others
	5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules that are derived from
T62710	Antitrypanosomal agent 6
	Antitrypanosomal agent 6 (compound 18a) 是一种有效的抗锥体虫剂，表现出良好的 ADME 特性。Antitrypanosomal agent 6 抗布氏锥虫 (T. brucei) 的活性比 Nifurtimox 高两倍以上，IC50为 0.47 μM。Antitrypanosomal agent 6 与 DNA 具有很强的相互作用，可以选择性的结合富含 AT 碱基的 DNA。
T66570	t-BuXPhos Pd G3
	Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T66570。
T67252	4Me t-BuXPhos Pd G3
	Methanesulfonato(2-di-t-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-tri-i-propylbiphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67252。
TNU1443	1,4-Anhydro-2-de oxy-3-O-(t-butyldiphenylsilyl-D-erythro-pent-1-enitol
	1,4-Anhydro-2-de oxy-3-O-(t-butyldiphenylsilyl-D-erythro-pent-1-enitol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1443，CAS号为 130277-32-6。
T67242	t-BuXPhos Pd G4
	Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67242。
T66069	t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
	t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66069，CAS号为 147489-06-3。
T63982	Anticancer agent 50
	Anticancer agent 50 (compound 6) 是 ABCB1 外排泵的有效调节剂，具有细胞毒活性和抗增殖活性。Anticancer agent 50 能够减少细胞周期蛋白 D1 的表达，并诱导 p53 表达。Anticancer agent 50 对 T 淋巴瘤表现出研究潜力。
T69821	AMP423
	AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive.
T77003	Ezabenlimab
	Ezabenlimab (BI-754091) 是一种抗PD-1单克隆抗体，结合PD-1的 Kd 为 6 nM (CHO 细胞)。Ezabenlimab 能够阻断PD-1与PD-L1和PD-L2的相互作用。Ezabenlimab 还增加 T 细胞内的 γ 干扰素分泌，抑制体内肿瘤生长。
T72670	PD-1/PD-L1-IN-13
	PD-1/PD-L1-IN-13 是一种有效的免疫检查点 PD-1/PD-L1抑制剂，对 PD-1/PD- L1 相互作用的 IC50值为 10.2 nM。PD-1/PD-L1-IN-13 在 Hepa1-6 同系小鼠模型中促进 CD8+T 细胞活化并延缓肿瘤生长。
T74911	ODN 24987
	ODN 24987，一种鸟嘌呤修饰的抑制性寡核苷酸（ODN），作用于TLR9，能够抑制IL-6和IFN-α的释放，适用于免疫紊乱研究。ODN 24987 序列为5’-C-C-T-G-G-C-c7G-G-G-G-3’。
T79707	Cholicamideβ	Necroptosis	Apoptosis
	Cholicamideβ（compound 6）为自组装小分子癌症疫苗佐剂，能够形成细胞毒性低的病毒样颗粒。该化合物与肽抗原结合，可增强树突状细胞的抗原呈递能力，并激活抗原特异性T细胞反应。Cholicamideβ还能引发细胞凋亡(apoptosis)和坏死(necrosis)。
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome...
TP1703	FliC, Serotype a (427-441), S.paratyphi A
	This is amino acids 427 to 441 fragment belongs to the FliC, serotype a of the S. FliC epitope recognized by a CD4+ T cell from naturally infected C57BL/6 mice is located in a region common to a number of distinct Salmonella serovars such as the S. paraty
T83852	EGFRvIII Peptide TFA PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide是一种合成肽，对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头，该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下，它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞（PBMCs）衍生的树突状细胞中，EGFRvIII peptide可诱导抗原呈递，进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5（TLR5）激动剂鞭毛蛋白B共同免疫EGFRvIII peptide（15 µg/动物），在正交GL261胶质母细胞瘤小鼠异种移植模型中，增加了CD8+ T细胞数量，减少了调节性T细胞（Tregs）数量，减少了肿瘤体积，并提高了生存率。
T35864	T-5342126
	T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen...
T78218	Ilaprazole sodium hydrate IY-81149 sodium hydrate	Proton pump	Membrane transporter/Ion channel
	Ilaprazole (IY-81149) sodium hydrate是一种具有口服活性的质子泵抑制剂，可以量依赖性地不可逆抑制H+/K+-ATPase，并在兔壁细胞制剂中展示出IC50为6μM的效力。该化合物主要用于胃溃疡的研究，并已证实是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。
T36070	(±)5(6)-EET
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...
T37812	6-O-Sulfo-β-cyclodextrin (sodium salt)
	6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)
T37068	NR-160
	NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
T72213	Efonidipine hydrochloride NZ-105 hydrochloride
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。
T25888	NSC-670224 NSC 670224
	NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related t
T61071	AX-024
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong ...
T37749	Benanomicin A
	Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans,P. oryzae, andA. niger(MICs = 3.13-50 μg/ml).1Benanomicin A inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B fr...
T37750	Benanomicin B (formate)
	Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans, andP. oryzae(MICs = 1.56-50 μg/ml).1Benanomicin B inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B from an act...
T35602	O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
	O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1 1.Taguchi, R., Naito, T., Sato, H., et al.Validated LC-MS/MS method for the simultaneous determination of amlodipine and its major metabolites in human plasma of hypertensive patientsTher. Drug Monit.39(6)625-631(2017)
TP1516	C-Reactive Protein (CRP) (77-82) C-Reactive Protein (CRP) 77-82
	C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring-shaped)
T36539	Nocardamine
	Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lo...
T35840	4-Amino-6-chloro-1,3-benzenedisulfonamide
	4-Amino-6-chloro-1,3-benzenedisulfonamide is a carbonic anhydrase inhibitor.1 Formulations containing this compound are diuretics.2 4-Amino-6-chloro-1,3-benzenedisulfonamide is detected as a hydrolysis product of chlorothiazide in the urine.2 Diuretics, including chlorothiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.3References1. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies ...
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe...
T36882	CAY10773
	CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ...
T35485	6-Prenylindole
	6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 \|1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity o...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

Cat.No: T37427

Synonym: 6-Prenylnaringenin,(±)-6-Prenylnaringenin

Target: Calcium Channel, HDAC

5-A-RU hydrochloride

Cat.No: T10165L

Synonym: 5-Amino-6-(D-ribitylamino)uracil hydrochloride

Target: Others

Cat.No: T11447

Target: GSK-3, DYRK

Myelin Basic Protein (87-99) Acetate

Cat.No: T21618L

Synonym: Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)

Target: Others

NLS PKKKRKV acetate(95088-49-6 free base)

Cat.No: TP1606L

Target: Others

Cat.No: T12079

Target: Proteasome

C-Reactive Protein (CRP) 77-82 acetate

Cat.No: TP1516L

Synonym: C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)

Target: Others

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Cat.No: T2548

Target: Glucocorticoid Receptor

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

PD-1/PD-L1-IN 6

Cat.No: T61968

Acetonitrilebis[2-diphenylphosphino-6-t-butylpyridine]cyclopentadienylruthenium(II) hexafluorophosphate

Cat.No: T67238

Cat.No: T10165

Synonym: 5-Amino-6-(D-ribitylamino)uracil

Target: Others

Antitrypanosomal agent 6

Cat.No: T62710

t-BuXPhos Pd G3

Cat.No: T66570

4Me t-BuXPhos Pd G3

Cat.No: T67252

1,4-Anhydro-2-de oxy-3-O-(t-butyldiphenylsilyl-D-erythro-pent-1-enitol

Cat.No: TNU1443

t-BuXPhos Pd G4

Cat.No: T67242

t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate

Cat.No: T66069

Anticancer agent 50

Cat.No: T63982

Cat.No: T69821

Cat.No: T77003

PD-1/PD-L1-IN-13

Cat.No: T72670

Cat.No: T74911

Cat.No: T79707

Target: Necroptosis

Cat.No: T37604

FliC, Serotype a (427-441), S.paratyphi A

Cat.No: TP1703

EGFRvIII Peptide TFA

Cat.No: T83852

Synonym: PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide

Cat.No: T35864

Ilaprazole sodium hydrate

Cat.No: T78218

Synonym: IY-81149 sodium hydrate

Target: Proton pump

Cat.No: T36070

6-O-Sulfo-β-cyclodextrin (sodium salt)

Cat.No: T37812

Cat.No: T37068

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Cat.No: T25888

Synonym: NSC 670224

Cat.No: T61071

Cat.No: T37749

Benanomicin B (formate)

Cat.No: T37750

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine

Cat.No: T35602

C-Reactive Protein (CRP) (77-82)

Cat.No: TP1516

Synonym: C-Reactive Protein (CRP) 77-82

Cat.No: T36539

4-Amino-6-chloro-1,3-benzenedisulfonamide

Cat.No: T35840

3-Hydroxykynurenamine

Cat.No: T68182

Edoxaban impurity 6

Cat.No: T37176

Cat.No: T36882

Cat.No: T35485

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Cat. No.	Product Name	Target	Signaling Pathways
T34765	T6A N-(6-Nebularinylcarbamoyl)threonine,t 6 A,t-6-A,t(6)A,N6-Threonylcarbamoyladenosine	Others	Others
	T6A (N6-Threonylcarbamoyladenosine) 是一种广泛存在具有普遍保守性的核苷，是修饰所必需的化合物。T6A 存在于负责转运 ANN 密码子的 tRNA 中。
T10183	6-Methoxytricin	Reductase	Endocrinology/Hormones; Metabolism
	6-Methoxytricin 是一种从艾蒿中分离出来的黄酮类化合物。6-Methoxytricin 是醛糖还原酶（AR）的抑制剂（IC50s：30.29 μM ），抑制 AKT 活性。6-Methoxytricin 具有抗炎活性，抑制生物细胞中的 T 细胞增殖和活化，可用于研究糖尿病。
TN6393	fulvotomentoside A	Others	Others
	fulvotomentoside A 可降低肠道中 IL-6 和 IL-17A 的过表达，并显着增加调节性 T 细胞特异性转录因子 Foxp3 的表达。这可能是Ful 改善肠道炎症的机制之一。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TN5307	Otophylloside T
	Otophylloside T 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5307，CAS号为 1642306-14-6。
T35908	Paraherquamide E
	Paraherquamide E is a fungal metabolite originally isolated from P. charlesii with anthelmintic and insecticidal activities. It is lethal to C. elegans (LD50 = 6 μg/ml). Paraherquamide E is also lethal to O. fasciatus (LD50 = 0.089 μg/nymph). Oral administration of paraherquamide E (0.5-4 mg/kg) reduces T. colubriformis fecal egg count in gerbils.
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
T37774	Thielavin A
	Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces...
T35415	α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
	α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol...
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T34765

Synonym: N-(6-Nebularinylcarbamoyl)threonine,t 6 A,t-6-A,t(6)A,N6-Threonylcarbamoyladenosine

Target: Others

6-Methoxytricin

Cat.No: T10183

Target: Reductase

fulvotomentoside A

Cat.No: TN6393

Target: Others

Cat.No: T6S1049

Target: ATPase

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Otophylloside T

Cat.No: TN5307

Paraherquamide E

Cat.No: T35908

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Cat.No: T37774

(rel)-Asperparaline A

Cat.No: T37609

α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)

Cat.No: T35415

Cat.No: T35741

Cat.No: T36438

Cat.No: T35779

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