ovary

NMS-E973 是一种有效且选择性的 Hsp90 抑制剂，与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障，具有抗肿瘤效果。

3-arylisoquinolinamine derivative is a compound with antitumor activity.

mTOR HDAC-IN-1 (Compound 50) 是一个具有选择性的mTOR 和HDAC 双重抑制剂，对mTOR 和HDAC1的IC50分别为0.49和0.91 nM。 mTOR HDAC-IN-1 可作为抗癌活性分子 （anti-cancer） 进行研究。该化合物的粉末形式不稳定，建议选择其他盐形式产品。

Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M(1) pKi=7.86, M(2) pKi=7.21, M(3) pKi=8.21); pA(2)=8.85, 8.71 and 8.57 in methacholine-induced contraction of trachea, ileum and urinary bladder, 8.19 in methacholine-induced bradycardia of right atrium in vitro, respectively.This compound is unstable in powder form and other related salt forms are recommened.

CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。

Solabegron (GW 427353) 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得 EC50=22 nM，可用于研究膀胱过度活跃和肠易激综合征。

YM 511 是一种高度特异性的非甾体芳香酶 (aromatase) 抑制剂。YM 511 竞争性抑制大鼠卵巢和人胎盘微粒体中的芳香酶活性 (IC50 分别为 0.4 和 0.12 nM)。YM 511 轻微抑制其他类固醇激素的产生。YM 511 具有用于抑制雌激素依赖性作用研究，不会影响其他类固醇激素的血清水平的潜力。

Berzosertib (VE-822) 是一种 ATR 抑制剂 (Ki<0.2 nM)，也抑制 ATM (Ki=34 nM)。Berzosertib 具有抗肿瘤活性，已用于研究卵巢肿瘤、卵巢浆液性肿瘤、成人实体瘤、晚期实体瘤和晚期实体瘤等治疗的试验。

J-104132 is a potetn and selective endothelin A B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ova

Mitopodozide, as an ethylhydrazide derivative of podophyllic acid, acts as a mitotic poison in carcinomas of the ovary.

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.

Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.2 1.Yamada, T., Iritani, M., Ohishi, H., et al.Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activitiesOrg. Biomol. Chem.5(24)3979-3986(2007) 2.Du, L., Munteanu, C., King, J.B., et al.An electrophilic natural product provides a safe and robust odor neutralization approach to counteract malodorous organosulfur metabolites encountered in skunk sprayJ. Nat. Prod.82(7)1989-1999(2019)

Clomesone 是一种合成的非甾体药物，可用作分子结构单元。它是一种常用于治疗女性不孕的药物，通过阻断大脑中雌激素的作用发挥作用，已被证明对患有多囊卵巢综合征和其他不孕问题的女性有效诱导排卵。

U92016A hydrochloride 是口服有效的5-HT1A 受体激动剂，代谢稳定。U92016A hydrochloride 表现出极高的内在活性，能够以高亲和力结合中国仓鼠卵巢细胞中表达的人 5-HT1A 受体，Ki 值为0.2 nM。

Turoctocog alfa 是一种来源于中国仓鼠卵巢 (CHO) 细胞的重组凝血因子 VIII (FVIII)。Turoctocog alfa 能够用于研究 A 型血友病。

Bitopertin (Paliflutine) 是一种有效的甘氨酸转运蛋白 1 (GlyT1) 抑制剂，对人 hGlyT1b 的 Ki 为 8.1 nM。

Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification.

Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.

Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.

NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP + - NU1085 (10 microM) for 72 h.

Jingzhaotoxin XI (JZTX-XI) 为抑制钠电导的化合物，其IC50值为124 nM。该化合物能够减缓CHO-K1细胞中Nav1.5通道的快速失活，EC50值为1.18±0.2 μM。

Coprelotamab (GB-221) 为针对EGFR2的IgG-κ类单克隆抗体。该化合物通常在CHO DG44 (中国仓鼠卵巢) 细胞中表达。

Davoceticept (ALPN-202; CD80 vIgD-Fc) 是一种靶向CTLA-4的单克隆抗体。它包含CD80的(1-107)片段，该片段通过肽基连接子与IGHG1 Fc连接。Davoceticept通常在CHO（中国仓鼠卵巢）细胞中表达。

Dovanvetmab (ZTS-00521505)，一种IgG1-κ型抗体，专一性靶向Felcat IL31，由CHO（Chinese Hamster Ovary）细胞主要表达。