molecular chaperone

TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂，可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率，激活热休克因子-1 并导致分子伴侣和抗炎活性升高，增强神经元和神经胶质细胞中 Hsp72 的表达。

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.

MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).

Claficapavir (A1752) is a potent nucleocapsid protein (NC) inhibitor that effectively binds the HIV-1 NC with a dissociation constant (Kd) of 20 nM, resulting in the inhibition of its chaperone properties. This specific molecular interaction leads to strong antiviral activity against HIV-1, with an IC50 of approximately 1 μM [1].

BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2 Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.

O-Carboranylphenoxyacetanilide，作为HIF-1α抑制剂，具有抑制HIF-1α激活的能力。该化合物在HeLa细胞中降低HIF转录活性 (IC50: 0.74 μM)。此外，O-Carboranylphenoxyacetanilide亦能够抑制HSP60分子伴侣活性及HSP60 ATPase活性。

Versipelostatin是一种新型的GRP78 Bip分子伴侣蛋白下调调节剂，可从链霉菌（4083-SVS6）菌株的培养液中分离得到。

HSP70 DnaK substrate peptide 是一种短肽，能与HSP70 DnaK分子伴侣结合并发挥作用。该肽段主要用于探究HSP70 DnaK在其分子伴侣功能中的机制。