Name: GFER Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01020
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 456

6-8日内发货

10 μg

¥ 740

6-8日内发货

20 μg

¥ 1,120

5日内发货

50 μg

¥ 1,970

5日内发货

100 μg

¥ 3,380

5日内发货

200 μg

¥ 5,850

5日内发货

500 μg

¥ 12,100

5日内发货

1 mg

¥ 17,300

5日内发货

生物活性

产品描述	GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
种属	Human
表达系统	E. coli
标签	N-6xHis
蛋白编号	P55789-2
氨基酸序列	Met1-Asp125
蛋白构建	Met1-Asp125
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Glycine-HCl, 150 mM NaCl, pH 2.5.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	HPO, HERV1, Hepatopoietin, GFER, FAD-linked sulfhydryl oxidase ALR, Augmenter of liver regeneration, ALR
内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.

化学信息

分子量	15 KDa (reducing condition)

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

GFER Protein, Human, Recombinant (His)

GFER Protein, Human, Recombinant (His)

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