maleimide

Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。

Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG3-maleimide is a PEG-based PROTAC linker primarily used for the synthesis of PROTACs[1]. Additionally, it serves as a cleavable 3-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].

DBCO-PEG4-Maleimide is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Azido-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized during PROTAC synthesis[1].

DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DSPE-PEG-Maleimide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound utilized for synthesizing PROTACs[1].

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG9-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DSPE-PEG(2000) maleimide 作为1,2-二硬脂酰-sn-磷脂醇（DSPE）的PEG化衍生物，广泛应用于体外及体内合成输送siRNA或小分子抗癌药物的脂质纳米粒子（LNPs）。在相关实验中，含有DSPE-PEG(2000) maleimide的LNPs，其封装了针对p53和K-RAS mRNA的siRNA，在PANC-1胰腺导管腺癌小鼠异种移植模型中成功诱导肿瘤退化。

N-Arachidonyl maleimide 是一种有效且不可逆的单酰基甘油脂肪酶 (MAGL) 抑制剂，IC50值为 140 nM。

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Maleimide, N-(5-(p-aminophenoxy)pentyl)- is a Drug Therapeutic Agent.

Maleimide-C10-NHS ester is an alkyl ether-based linker for PROTAC synthesis.

DSPE-PEG-Maleimide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64567。

Glutathione maleimide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.

DSPE-PEG-Maleimide (MW 2000) 是一种由 DSPE 和马来酰亚胺基团组成的 PEG 化合物。DSPE-PEG-Maleimide (MW 2000) 可用于构建脂质体。

Biotin-PEG7-Maleimide是一种能与硫醇基(SH)反应的生物素化试剂，适用于作为ADC药物连接偶联剂(Drug-Linker Conjugates for ADC)。

(+)-JQ1 maleimide是一种探针，由一个与BRD4配体JQ1通过PEG2连接器相连的含有活性的maleimide组成。它可用于COFFEE方法（COvalent Functionalization Followed by E3 Electroporation），在该方法中，(+)-JQ1 maleimide与VHL共价连接后通过电穿孔导入活细胞。E3连接酶在细胞内与BRD4形成复合物，引导其降解。