maleimide

Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。

Azido-PEG3-maleimide is a PEG-based PROTAC linker primarily used for the synthesis of PROTACs[1]. Additionally, it serves as a cleavable 3-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].

Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative containing a maleimide group commonly employed as a linker for the synthesis of PROteolysis TAgeting Chimeras (PROTACs)[1].

Azido-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized during PROTAC synthesis[1].

DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DSPE-PEG-Maleimide (MW 5000) 是一种功能化的磷脂衍生物，常用于脂质体和纳米颗粒的构建。其末端马来酰亚胺基团可与含巯基的生物分子（如抗体或多肽）进行稳定的化学偶联。

Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound utilized for synthesizing PROTACs[1].

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG9-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO4-PEG2-Maleimide 是一种 PROTAC linker，属于 PEG 类。此化合物包含 TCO 和 Maleimide 基团，可分别与 tetrazine 基或硫氧基 (thiol group) 进行特异性的“click”反应或“巯基-丙烯酰胺”反应。

TCO4-PEG2-Maleimide 是一种 PROTAC linker，属于 PEG 类。它包含 TCO 和 Maleimide 基团，能够分别与 tetrazine 基或硫氧基 (thiol group) 进行特定的“click”反应，或参与“巯基-丙烯酰胺”反应。

TCO4-PEG7-Maleimide 是一种 PROTAC linker，属于 PEG 类化合物。该化合物含有 TCO 和 Maleimide 基团，能够分别与 tetrazine 基或硫氧基 (thiol group) 进行特异性“click”反应或“巯基-丙烯酰胺”反应。

TCO4-PEG3-Maleimide 是一种属于 PEG 类的 PROTAC linker。它包含 TCO 和 Maleimide 基团，能够分别与 tetrazine 基或硫氧基 (thiol group) 进行特异性的“click”反应或“巯基-丙烯酰胺”反应。

TCO4-PEG3-Maleimide 是一种 PEG 类的 PROTAC linker。它包含 TCO 和 Maleimide 基团，可以分别与 tetrazine 基或者硫氧基 (thiol group) 进行特异性的“click”反应或“巯基-丙烯酰胺”反应。

Maleimide-Val-Ala-PAB-SNS032 是一种由 ADC 毒素和连接子组成的化合物。SNS032 作为 CDK 抑制剂，可抑制癌细胞活力并在 G1/S 期阻滞细胞周期。Maleimide-Val-Ala-PAB 作为可裂解的 ADC 连接子，Maleimide-Val-Ala-PAB-SNS032 可用于ADC分子的合成。

Maleimide-Ph(3,5-F)-PEG4-Val-Ala 是一种 PEG 类的可裂解 ADC linker，适用于合成抗体-药物偶联物 (ADCs)。

Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 是一种用于 ADC 的药物-连接子偶联物。该化合物由拓扑异构酶 1 抑制剂 (Topi MF-6) 和可裂解的 Maleimide-Ph(3,5-F)-PEG4-Val-Ala linker 组成，适用于 ADCs 的合成。

Sulfo DBCO-PEG4-Maleimide TEA 是一种 PEG 类 PROTAC linker，可用于合成 PROTAC 分子。作为一种点击化学试剂，Sulfo DBCO-PEG4-Maleimide (TEA) 含有 DBCO 基团，能够与含有 Azide 基团的分子进行环张力促进的炔-叠氮环加成反应 (SPAAC)。

N-Arachidonyl maleimide 是一种有效且不可逆的单酰基甘油脂肪酶 (MAGL) 抑制剂，IC50值为 140 nM。

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh