m 25

Smoothened (Smo) receptor antagonist

M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.

Sonidegib metabolite M25 is a smoothened (SMO) antagonist.

Anti-Mouse Human IL-7 Antibody (M25) 是一种来自小鼠的IgG2b抗体抑制剂，用于针对小鼠或人类IL-7。

TT15 is an agonist of the GLP-1R.

m-PEG25-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG25-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG25-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG25-Propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

ZM 253270 is an nonpeptide neurokinin A antagonist.

LM 2510 is a bioactive chemical.

Diphenhydramine (Syntedril) 是第一代具有抗胆碱能作用的H1 受体拮抗剂，它能透过血脑屏障。

AM251 是一种选择性大麻素1 受体拮抗剂，IC50=8 nM，是一种 GPR55 的激动剂，EC50=39 nM。

KDOAM-25 citrate 是有效且具有高选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂，对 KDM5A，KDM5B，KDM5C，KDM5D 的IC50分别为 71 nM，19 nM，69 nM，69 nM。用KDOAM-25 citrate 处理的多发性骨髓瘤 MM1S 细胞显示转录起始位点的整体 H3K4 甲基化增加，增殖受损。

KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor

KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at transcriptional start sites and reduces proliferation in multiple myeloma MM1S cells.

TM-25659是一种具有 PDZ 结合图案的转录协同激活剂（TAZ）的调节剂，具有抗骨质疏松和抗肥胖的活性。

YM-254890 是一种从 Chromobacterium sp 中分离的大环己肽，是一种具有选择性和高效性的 Gαq 11 蛋白抑制剂，抑制 ADP 诱导的血小板凝集，抑制 G 蛋白信号传导。

δ receptor antagonist

Benzoic acid, m-(2,5-dimethylpyrrol-1-yl)- is a bioactive chemical.

Benzoic acid, m-(2,5-dimethylpyrrol-1-yl)-, hydrazide is a bioactive chemical.

KDOAM-25 trihydrochloride 是一种有效的、高度选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂，能够作用于 KDM5A (IC50: 71 nM)、KDM5B (IC50: 19 nM)、KDM5C (IC50: 69 nM)、KDM5D (IC50: 69 nM)。KDOAM-25 trihydrochloride 能够提高转录起始位点的整体 H3K4 甲基化，可阻碍多发性骨髓瘤 MM1S 细胞的增殖。

PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1) programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro.

DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate test and in the second phase of the formalin test.