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顶部生物活性储存和溶解信息计算器

Anti-ENPP7 Antibody (8R662)

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产品编号 TMAY-01285

别名 Gm254, ectonucleotide pyrophosphatase/phosphodiesterase 7, Alk-SMase

Anti-ENPP7 Antibody (8R662) 是一种 Mouse 抗体，靶向 ENPP7。Anti-ENPP7 Antibody (8R662) 可用于 ICC/IF。

Anti-ENPP7 Antibody (8R662)

Anti-ENPP7 Antibody (8R662)

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产品编号 TMAY-01285 别名 Gm254, ectonucleotide pyrophosphatase/phosphodiesterase 7, Alk-SMase

Anti-ENPP7 Antibody (8R662) 是一种 Mouse 抗体，靶向 ENPP7。Anti-ENPP7 Antibody (8R662) 可用于 ICC/IF。

规格价格库存数量
100 μL
¥ 1,684
5日内发货
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产品介绍

生物活性
产品描述
Anti-ENPP7 Antibody (8R662) is a Mouse antibody targeting ENPP7. Anti-ENPP7 Antibody (8R662) can be used in ICC/IF.
别名Gm254, ectonucleotide pyrophosphatase/phosphodiesterase 7, Alk-SMase
Ig Type
Mouse IgG2b
克隆号
8R662
交叉反应
Human
特异性
Human ENPP7
验证活性
Immunofluorescence staining of Human ENPP7 in HT29 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human ENPP7 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cell membrane.
应用ICC/IF
推荐剂量
ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ENPP7 (rh ENPP7; TMPY-01070; NP_848638.2; Met1-Ser439). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to thenucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human ENPP7 protein (TMPY-01070)
抗原种属
Human
研究领域
Phosphatases and Regulators
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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