hyperlipidemia

Pedunculoside 是从 Ilex rotunda Thunb 中提取的，通过对脂质形成和脂肪酸 β-氧化的调节而发挥降脂作用。

Choline Fenofibrate (Trilipix) 是 Fenofibric acid 的胆碱盐，在胃肠道中释放游离的 Fenofibric acid。Fenofibric acid 是一种合成的苯氧基异丁酸衍生物和具有抗高血脂活性的前药。

Cerivastatin 是一种具有口服活性和高效性的 HMG-CoA 还原酶抑制剂，具有抗癌和降脂的作用。Cerivastatin 可降低低密度脂蛋白胆固醇水平，抑制 MDA-MB-231 细胞的增殖和侵袭，可用于研究原发性高脂血症。

Tenivastatin (Simvastatin acid) 是一种抗高脂血症的 HMG-CoA 还原酶抑制剂，抑制活性氧 (ROS) 产生，可用于研究原发性高脂血症。

Monatepil maleate (AJ-2615 maleate) 是一种具有口服活性的 Ca2+-通道和α1-肾上腺素受体拮抗剂，也是非竞争性肝酰辅酶A：胆固醇酰基转移酶（ACAT）抑制剂，具有抗高血压活性。Monatepil maleate 可用于研究高脂血症和动脉粥样硬化。

Eflucimibe (L0081) 是一种酰基辅酶A：胆固醇酰基转移酶抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，可用于研究动脉粥样硬化和高脂血症。

Lifibrol (U-83860) 是一种胆固醇合成抑制剂。Lifibrol 具有抗胆固醇和降血脂的作用，可促进高胆固醇血症和混合型高脂血症患者体内低密度脂蛋白载脂蛋白 B-100 的转化。

Sultosilic acid piperazine salt (A-585) 是一种新型降脂化合物，可用于研究IIb型家族性联合高脂血症。

Berberine ursodeoxycholate (HTD1801) 是一种口服有效的降血脂剂 ，是 Berberine 和 Ursodeoxycholic acid 的一种离子盐。Berberine ursodeoxycholate 具有广泛的代谢活性，可显著降低肝脏脂肪含量。Berberine ursodeoxycholate 可用于研究高脂血症、非酒精性脂肪性肝炎 (NASH) 和糖尿病。

Acipimox (K-9321) 是烟酸类似物，能够急性抑制脂解作用，抑制全身游离脂肪水平，改善胰岛素敏感性。

Tiratricol (3,3',5-Triiodothyroacetic acid) 是 T3 和 T4 甲状腺激素的代谢物；促进高脂血症、局部脂肪营养不良和肥胖。它已用于研究 Allan-Herndon-Dudley 综合征治疗的试验。

Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。

Cerivastatin sodium (BAY W 6228 sodium) 是一种具有口服活性和高效性的 HMG-CoA 还原酶抑制剂，具有降脂活性，可降低低密度脂蛋白胆固醇水平。Cerivastatin sodium 具有抗癌作用，可用于研究原发性高脂血症。

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa

LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states.

LY88074 Trimethyl ether is useful for inhibiting various conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia.

Kanglexin 是一种口服有效的蒽醌类化合物。它通过抑制NLRP3炎症小体的激活和细胞焦亡 (pyroptosis) 产生心脏保护作用。此外，Kanglexin 可以通过FGFR1 ERK信号通路促进血管生成，加速糖尿病伤口的愈合。该化合物还具备降脂和抑制血管平滑肌细胞去分化的作用，有潜力用于研究高脂血症、脂肪肝及动脉粥样硬化等疾病。

Protodioscin (Furostanol I) 是一种山药根茎中的主要甾体皂苷，具有抗高血脂、抗癌活性。

Acetiromate is a drug of antilipidemic. It is used to treat hyperlipidemia.

Binifibrate is a hyperlipemiant drug used for the treatment of hyperlipidemia.

SMP-797 HCl, an ACAT (acyl-CoA-cholesterol acyltransferase) inhibitor, is used potentially for the treatment of Hyperlipidemia.

Sodelglitazar, a PPAR agonist, is used potentially for the treatment of hyperlipidemia and type 2 diabetes.

AR-12456 is a Trapidil derivative that prevents serum hyperlipidemia in guinea pigs.

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4 1.Makishima, M., Okamoto, A.Y., Repa, J.J., et al.Identification of a nuclear receptor for bile acidsScience2841362-1365(1999) 2.Barbier, O., Torra, I.P., Sirvent, A., et al.FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activityGastroenterology1241926-1940(2003) 3.Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5)1380-1390(2007) 4.Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an anatagonist ligand for FXRScience296(5573)1703-1706(2002) 5.Cui, J., Huang, L., Zhao, A., et al.Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pumpThe Journal of Biological Chemisty278(12)10214-10220(2003) 6.Wu, J., Xia, C., Meier, J., et al.The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptorMolecular Endocrinology16(7)1590-1597(2002)