Thiazolo[5,4-c]pyridin-4(5H)-one(compound 17)是一种用于诊断成像TDP-43 (Transactive response(TAR) DNA binding protein 43 kDa)的化合物,常用于神经退行性疾病的正电子发射断层扫描(PET)成像,如肌萎缩性侧索硬化症(ALS)、阿尔茨海默病(AD)、额颞叶痴呆(FTD)和边缘显性年龄相关的TDP-43脑病(LATE)。
NIR dye-1 is a near-infrared (NIR) fluorescent dye which has absorption and emission in the NIR region while retaining an optically tunable hydroxyl group.