Name: BMV109
Brand: TargetMol
SKU: T85864
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

3-6月

50 mg

待询

3-6月

100 mg

待询

3-6月

生物活性

产品描述	BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].
体外活性	BMV109（化合物 8；0.05 µM、0.1 µM、0.5 µM、1 µM、5 µM）能在活 RAW 细胞中均等强度地标记所有目标半胱氨酸组织蛋白酶（B、S、L、X）[1]。
体内活性	在乳腺癌小鼠模型中，BMV109（化合物 8；20 nmol；静脉注射）实现了肿瘤特异性荧光信号 [1]。Animal Model: Balb/c mice bearing 4T1 cells [1] Dosage: 20 nmol Administration: Tail vein Result: Observe robust tumor-specific activation of fluorescence with high overall intensity.
别名	BMV-109, BMV109, BMV 109

化学信息

分子量	2138.37
分子式	C₁₀₇H₁₀₈F₄N₁₀O₂₃S₅
CAS No.	1458731-58-2
Smiles	S(=O)(=O)(C1=C(C=2C3=C([O+]=C4C2C=CC(=C4)N5C=6C(CC5)=CC(S(=O)(=O)O)=CC6)C=C(C=C3)N7C=8C(CC7)=CC(S(=O)(=O)[O-])=CC8)C=CC=C1)N9CCC(C(NCCNC(=O)C%10=C(F)C(F)=C(OCC([C@@H](NC([C@H](CC%11=CC=CC=C%11)NC(OCC%12=CC=CC=C%12)=O)=O)CCCCNC(CCCCCN%13C=%14C(C(C)(C)C%13=CC=CC=CC%15=[N+](CC)C=%16C(C%15(C)C)=CC(S(=O)(=O)[O-])=CC%16)=CC(S(=O)(=O)O)=CC%14)=O)=O)C(F)=C%10F)=O)CC9

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.

BMV109