nk1, human

Vofopitant dihydrochloride (GR 205171A) 是一种可口服且具有选择性的速激肽 NK1 受体拮抗剂，对 [3H]SP 与 NK1 结合有抑制作用， pKi 值分别为 9.5 和 10.6。Vofopitant dihydrochloride 是治疗病理性呕吐的潜在化合物。

Vofopitant (GR 205171) 是一种有效的 NK1 receptor 拮抗剂，具有抗焦虑和止吐活性，可用于研究创伤后应激障碍(PTSD)。

Aprepitant 是选择性和高亲和力的神经激肽1受体拮抗剂，Kd 值为86 pM。

N-Acetyl-L-tryptophan (N-acetyltryptophan) 是内源性代谢产物的一种。

CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on

Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor.

Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。

L 760735 is a NK1 receptor antagonist.

human tachykinin NK1 receptor antagonist

L 741671 is an antagonist of the neurokinin-1 receptor.

L-703,606 is a potent, selective human NK1 receptor antagonist.

Rolapitant (SCH619734) hydrochloride 是一种高效选择性和具有口服活性的神经激肽 1 (NK1) 受体拮抗剂，Ki 值为 0.66 nM。Rolapitant hydrochloride (Rolapitant HCl) 不与 CYP3A4 产生互作。Rolapitant hydrochloride 在雪貂呕吐模型中显示出强效的中枢介导的止吐活性。

Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy.

Vestipitant, also known as GW597599, is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) receptor blockade in the alleviation of anxiety and, possibly, depression. It is under development as a potential antiemetic and anxiolytic drug, and as a treatment for tinnitusand insomnia.

Hemokinin 1, human TFA 是选择性的速激肽神经激肽 1 (NK1) 受体完全激动剂。Hemokinin 1, human TFA 也是 NK2和 NK3受体的完全激动剂。Hemokinin 1, human TFA 可以产生非阿片样物质的缓解疼痛作用。

Fosnetupitant chloride monohydrochloride（Pronetupitant chloride monohydrochloride）为NK1受体拮抗剂，对人NK1受体和NK3受体的pKi分别为9.5和6.1。它是奈妥匹坦的亚甲基磷酸酯前体。

CP 122721 hydrochloride是一种有效的非肽选择性neurokinin NK1非肽拮抗剂，针对IM-9细胞中表达的人NK1受体展示出9.8的pIC50值，具备抗焦虑和抗抑郁样效应。

Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。

Substance P (Neurokinin P) 是一种神经肽，其内源性受体是神经激肽1受体，在中枢神经系统中作为神经递质和神经调节剂。

Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with Ki values of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.

Hemokinin 1 (mouse) acetate(208041-90-1 free base) 是一种选择性兴奋剂 1 受体激动剂，对人 NK1 受体的 Ki 值为 0.175 nM，对人 NK2 受体的 Ki 值为 560 nM。

Hemokinin 1 (human) acetate(491851-53-7 free base) 是一种内源性 P 物质同系物，是速激肽 NK1 受体的选择性激动剂（NK1、NK3 和 NK2 受体的 IC50 值分别为 1.8、370 和 480 nM）。在体外对 B 细胞具有增殖和抗凋亡作用，在体内具有抗高血压作用。

Endogenous human tachykinin-like peptide and potent agonist for NK1 receptors (EC50 = 1 nM).