baz2a

GSK8573 是 GSK2801 的非活性对照化合物。它与BRD9具有结合活性，Kd 值为 1.04 μM。

BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A B over CECR2 and >100-fold selectivity over all other bromodomains.

GSK2801 是一种有口服活性的和细胞活性的乙酰赖氨酸竞争性BAZ2A 和BAZ2B 溴结构域选择性抑制剂，Kd 值分别为 136 nM 和 257 nM。

BAZ2A B ligand 1 (compound 1) 是一种PROTAC靶蛋白配体 (Ligand for Target Protein for PROTAC)，可用于合成dBAZ2。

dBAZ2 是一种用于降解BAZ2A和BAZ2B的首创PROTAC降解剂，其对BAZ2A和BAZ2B的DC50值分别为180 nM和250 nM。

dBAZ2B是一种BAZ2B PROTAC降解剂，其DC50值为19 nM。(Pink: BAZ2A B ligand; Black: linker; Blue: CRBN Ligand)