aldolase

Aldometanib (LXY-05-029) 是一种具有口服活性的醛缩酶抑制剂，可以阻止FBP 与v-ATPase 相关的醛缩酶结合，并激活溶酶体 AMPK 。Aldometanib 可用于代谢稳态的研究。

Aldolase 是一种糖酵解酶，也是 VATPase 复合物的组成成分，可催化 fructose 1,6-bisphosphate 可逆裂解为 dihydroxyacetone phosphate 与 D-glyceraldehyde 3-phosphate。Aldolase 在能量代谢、代谢流调控及糖酵解相关酶学研究中具有核心作用。

Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) 是一种I型醛缩酶，可催化N-乙酰神经氨酸 (Neu5Ac) 的可逆裂解，生成丙酮酸和N-乙酰-D-甘露糖胺 (ManNAc)，而且反应平衡倾向于Neu5Ac的裂解。

Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物，一种抗生素和抗原虫剂，具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。

TLK117 是一种 GSTs 抑制剂，可减轻肺纤维化的严重程度，可用于研究特发性肺纤维化。

FBA-IN-1 是果糖-1,6-二磷酸醛缩酶（FBA） 共价变构抑制剂，具有抗病毒和抗真菌活性，抑制白色念珠菌，可用于研究真菌感染。

Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected and hybrids were synthesized via substitution at piperazinyl-N4. The reaction of piperazinyl-NH of ciprofloxacin with selected drugs resulted in pronounced growth inhibition of standard as well as resistant bacterial strains[2]. The parent piperazine 6 was found to exhibit a reasonable activity toward the HeLa and MDA MB 231 tumor cell lines (IC50= 9.2 and 8.4 μΜ, respectively)[3]. Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[4].

KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.

Phosphoglycolohydroxamic acid 是有效抑制醛缩酶(aldolase)和磷酸丙糖异构酶(triose-phosphate isomerase)的化合物，同时在抗菌和抗真菌领域的研究中具有应用潜力。

N-Acetylneuraminate lyase (CgNal)（亦称Sialic acid aldolase (CgNal)）是一种醛缩酶，在生化研究中有着广泛应用。该酶催化丙酮酸和N-acetyl-d-mannosamine (ManNAc) 通过一种可逆的缩合反应生成sialic acid N-acetylneuraminic acid (Neu5Ac)。

2-Deoxyribose 5-phosphate disodium 是一种2-deoxyribose-5-phosphate aldolase (DERA) 的底物，该酶为I类醛缩酶，负责催化可逆醛缩反应，且在过程中不需要任何辅助因子。

2-keto-3-deoxy-6-phosphogluconate 是一种内源性代谢物，存在于大肠杆菌中。在人类和植物病原体中，它是 Entner-Doudoroff (ED) 途径以及糖酸和糖聚合物分解途径的重要中间产物，由 KDPG 醛缩酶催化形成。

DL-4-Hydroxy-2-ketoglutarate lithium是一种4-hydroxy-2-oxoglutarate aldolase(HOGA)的底物，能够被HOGA为丙酮酸和乙醛酸。

DL-4-Hydroxy-2-ketoglutarate是一种γ-酮酸，同时也是谷氨酸的结构类似物。作为 4-羟基-2-酮戊二酸醛缩酶 (HOGA1) 和谷氨酸-草酰乙酸转氨酶 (GOT) 等酶的生化底物，DL-4-Hydroxy-2-ketoglutarate还可作为赖氨酸类似物，用于酶抑制机制和代谢通路研究。