PD 117588 is a quinolone against bacterial isolates from cancer patients. PD 117558 has a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative st
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+.
Antibacterial agent 39 is a potent compound that exhibits antibacterial properties. It effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent.
Antibacterial Agent 45 (AA45) exemplifies a potent antibacterial compound that effectively reduces the minimal inhibitory concentration (MIC) value of Ceftazidime, another antibacterial agent.
Antibacterial Agent 47 demonstrates potent antibacterial activity as an adjunct therapy to parenteral antibiotic Ceftazidime. By effectively reducing the minimum inhibitory concentration (MIC) of Ceftazidime, Antibacterial Agent 47 acts as a highly promising antimicrobial agent, thereby enhancing the overall efficacy of the treatment.
Antibacterial Agent 35 (AA35) is a potent antibacterial agent that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent.
Antibacterial agent 35 is a compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, enhancing its antibacterial activity.
Antibacterial Agent 33, a potent antibacterial compound, effectively decreases the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent.
Antibacterial Agent 58 (AA58) is a potent antibacterial compound that effectively reduces the minimum inhibitory concentration (MIC) value of Ceftazidime, another antibacterial agent.
Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.
1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.