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Tenofovir Disoproxil Fumarate

产品编号 T2409L CAS 202138-50-9

别名: GS-1278 Disoproxil Fumarate, Tenofovir DF, 富马酸替诺福韦酯

Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) 是一种核苷酸逆转录酶抑制剂，有潜力研究艾滋病和慢性乙型肝炎。

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Tenofovir Disoproxil Fumarate Chemical Structure

Tenofovir Disoproxil Fumarate, CAS 202138-50-9

规格	价格/CNY	货期
10 mg	￥ 397	现货
50 mg	￥ 843	现货
100 mg	￥ 1,240	现货
200 mg	￥ 1,675	现货
500 mg	￥ 3,355	现货
1 mL * 10 mM (in DMSO)	￥ 373	现货

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其他形式的 Tenofovir Disoproxil Fumarate:

Tenofovir Disoproxil
现货
Tenofovir disoproxil aspartate
询价

选择批次

纯度: 99.86%

纯度: 99.16%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults.
体外活性	Tenofovir shows cytotoxic effects on cell viability in HK-2 cells in MTT assay (IC50: 9.21/2.77 μM at 48/72 h). Tenofovir lowers ATP levels in HK-2 cells. Tenofovir (3.0-28.8 μM) promotes protein carbonylation and oxidative stress in HK-2 cells. In addition, Tenofovir promotes apoptosis induced via mitochondrial damage in HK-2 cells. M48U1 and Tenofovir formulated in 0.25% HEC each inhibits the replication of both X4-tropic HIV-1IIIb and R5-tropic HIV-1BaL in activated PBMCs and inhibits patient-derived HIV-1 isolates and several laboratory strains. Aforesaid mixture exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1BaL and is not toxic to PBMCs.
体内活性	Tenofovir Disoproxil Fumarate (20/50/140/300?mg/kg) administered to BLT mice, shows dose-dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50/140/300?mg/kg) obviously lowers HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5/1.5/5.0 mg/kg/day, p.o.) promotes a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection.
激酶实验	HAT and HDAC Activity Assays :After homogenization of cardiac tissues, nucleoproteins are extracted using a Nuclear Extract Kit according to the manufacturer's instructions. HAT and HDAC activities of the nuclear protein extracts are determined using a colorimetric assay included in the HAT and HDAC assay kits.
细胞实验	Cells are plated into 48-well tissue culture plates (39,000 cells/mL) and allowed to grow for 48 h followed by treatment with vehicle or Tenofovir. Following the treatment period, cell viability is assessed using the MTT assay. The MTT assay relies on the conversion of tetrazolium dye 3-(4,5-dimethlthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to formazan by NAD(P)H-dependent oxidoreductases.
动物实验	Tenofovir Disoproxil Fumarate is prepared in a placebo control. Twenty adult chronic WHV carrier woodchucks are stratified equally by age, sex, body weight, and serum GGT activity into five treatment groups consisting of four animals each: (i) Tenofovir Disoproxil Fumarate at 15.0 mg/kg once per day, (ii) Tenofovir Disoproxil Fumarate at 5.0 mg/kg/day, (iii) Tenofovir Disoproxil Fumarate at 1.5 mg/kg/day, (iv) Tenofovir Disoproxil Fumarate at 0.5 mg/kg/day, and (v) a placebo control. The woodchucks are treated daily for 4 weeks and observed for an additional 12 weeks following cessation of drug treatment.

别名	GS-1278 Disoproxil Fumarate, Tenofovir DF, 富马酸替诺福韦酯
分子量	635.51
分子式	C19H30N5O10P·C4H4O4
CAS No.	202138-50-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 44 mg/mL (69.23 mM)

DMSO: 128 mg/mL (201.41 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.5735 mL	7.8677 mL	15.7354 mL	39.3385 mL
	5 mM	0.3147 mL	1.5735 mL	3.1471 mL	7.8677 mL
	10 mM	0.1574 mL	0.7868 mL	1.5735 mL	3.9338 mL
	20 mM	0.0787 mL	0.3934 mL	0.7868 mL	1.9669 mL
	50 mM	0.0315 mL	0.1574 mL	0.3147 mL	0.7868 mL
DMSO	100 mM	0.0157 mL	0.0787 mL	0.1574 mL	0.3934 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Ray AS, et al. Antimicrob Agents Chemother, 2006, 50(10), 3297-3304. 2. Birkus G, et al. Antimicrob Agents Chemother, 2002, 46(3), 716-723. 3. Delaney WE 4th, et al. Antimicrob Agents Chemother, 2006, 50(7), 2471-2477. 4. Cihlar T, et al. Antiviral Res, 2002, 54(1), 37-45. 5. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098.

文献引用

1. Wu M, Li M, Liu W, et al.Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.Cell Reports.2023, 42(7): 112802.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Tenofovir Disoproxil Fumarate 202138-50-9 Microbiology/Virology Proteases/Proteasome HBV HIV Protease Reverse Transcriptase Hepatitis B virus HIV GS-1278 Disoproxil Fumarate GS 4331 Inhibitor GS4331 Tenofovir DF 富马酸替诺福韦酯 GS-4331 inhibit Tenofovir Disoproxil Bis(POC)-PMPA Human immunodeficiency virus inhibitor

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Tenofovir Disoproxil Fumarate

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

文献引用

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords