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SUN11602

SUN11602

产品编号 T3714   CAS 704869-38-5
别名: SUN 11602

SUN11602 是新型的碱性苯胺化合物,具有成纤维细胞生长因子特性。

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SUN11602 Chemical Structure
SUN11602, CAS 704869-38-5
规格 价格/CNY 货期 数量
1 mg ¥ 248 现货
5 mg ¥ 578 现货
10 mg ¥ 995 现货
25 mg ¥ 1,980 现货
50 mg ¥ 3,290 现货
100 mg ¥ 4,120 现货
1 mL * 10 mM (in DMSO) ¥ 638 现货
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
Venetoclax限时半价
MG-132限时半价
产品目录号及名称: SUN11602 (T3714)
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纯度: 98.43%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevents glutamate-induced neuronal death. It also increases levels of CALB1 gene expression in cerebrocortical neurons and triggers phosphorylation of FGFR and ERK1/2.
体外活性 Physiological actions of SUN11602 mimic several phenomena of the neuroprotection that is induced by bFGF. SUN11602 plays a pivotal role in allowing primary cultured neurons to survive in adverse environments of glutamate toxicity and activating intracellular key molecules that are involved in the neuroprotective mechanisms. These actions are quite similar to those of bFGF. Such neuroprotective mechanisms are specific and distinctive to SUN11602 and bFGF and differs clearly from those of the other growth factors that are investigated. But unlike bFGF, SUN11602 can either directly or indirectly trigger the phosphorylation of the cytosolic domain of the FGFR without binding to the extracellular domain of the FGFR-1[1]. SUN11602 demonstrates no cell proliferative activity of somatic cells, unlike bFGF. SUN11602 significantly affects neuronal survival in adverse conditions through a FGFR1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1–MEK/ERK) signaling pathway[2].
体内活性 In WT mice, SUN11602 and bFGF increase the levels of newly synthesized Calb in cerebrocortical neurons and suppress the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. In contrast, Calb levels remain unchanged in Calb-/- mice after exposure to SUN11602 or bFGF, and due to a loss of function of the gene, these neurons are no longer resistant to toxic conditions of glutamate[1]. Neuroprotective activities of SUN11602 and FGF-2 are due to exogenously induced hyperexpression of CalB in hippocampal neurons. The pharmacokinetic properties of SUN11602 appear to hold promise in terms of bioavailability (>65%) after oral administration in rodents (rats and mice) and dogs (beagles)[2].
细胞实验 Actinomycin D or cycloheximide is first added to the cultures, and, 2 h later, SUN11602 or bFGF is added. After a 24 h incubation, neurons in the cultures are exposed to 150 μM glutamate for another 24 h, and cell viability is determined by a (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay.(Only for Reference)
别名 SUN 11602
分子量 451.6
分子式 C26H37N5O2
CAS No. 704869-38-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 9 mg/mL (20 mM)

DMSO: 22.6 mg/mL (50 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.2143 mL 11.0717 mL 22.1435 mL 55.3587 mL
5 mM 0.4429 mL 2.2143 mL 4.4287 mL 11.0717 mL
10 mM 0.2214 mL 1.1072 mL 2.2143 mL 5.5359 mL
20 mM 0.1107 mL 0.5536 mL 1.1072 mL 2.7679 mL
DMSO 50 mM 0.0443 mL 0.2214 mL 0.4429 mL 1.1072 mL

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TargetMol Library Books参考文献

1. Murayama N, et al. ACS Chem Neurosci. 2013, 4(2):266-76. 2. Murayama N, et al. Brain Res. 2015, 1594:71-81.
ERα degrader-2 Ergosterol peroxide Pachymic acid Dehydroglyasperin C MEK-IN-6 DEL-22379 NMDAR/TRPM4-IN-2 Alpinumisoflavone

相关化合物库

该产品包含在如下化合物库中:
酪氨酸激酶分子库 激酶抑制剂库 抗卵巢癌化合物库 癌细胞分化化合物库 抗衰老化合物库 抗乳腺癌化合物库 抗胰腺癌化合物库 抗癌化合物库 NO PAINS 化合物库 细胞因子抑制剂库

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Keywords

SUN11602 704869-38-5 Angiogenesis MAPK Tyrosine Kinase/Adaptors ERK FGFR inhibit Fibroblast growth factor receptor SUN 11602 Inhibitor SUN-11602 inhibitor

 

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