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FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

产品编号 TMPY-00341
别名: CEK2, HSFGFR3EX, fibroblast growth factor receptor 3, JTK4, FGFR3 α(IIIb), CD333, ACH

FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.

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FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
规格 价格/CNY 货期 数量
200 μg ¥ 5,770 现货
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产品目录号及名称: FGFR3 Protein, Human, Recombinant (alpha IIIb, His) (TMPY-00341)
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生物活性 Testing in progress
产品描述 FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P22607-2
别名 CEK2, HSFGFR3EX, fibroblast growth factor receptor 3, JTK4, FGFR3 α(IIIb), CD333, ACH
蛋白构建 The Human FGFR3(alpha(IIIb)) (NP_001156685.1) (Met1-Gly377) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE.

TargetMol

分子量 40 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

FGFR3 Protein, Human, Recombinant (alpha IIIb, His) CEK2 JTK-4 HSFGFR3EX CEK 2 CEK-2 fibroblast growth factor receptor 3 JTK4 CD-333 FGFR3 α(IIIb) CD 333 JTK 4 CD333 ACH recombinant recombinant-proteins proteins protein

 

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