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FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

产品编号 TMPY-06036
别名: FGFR-1, FLG, CD331, HH2, FLT2, KAL2, FGFBR, HBGFR, CEK, HRTFDS, fibroblast growth factor receptor 1, OGD, FGFR1 α (IIIc), N-SAM, bFGF-R-1, FLT-2, BFGFR

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.

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FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)
规格 价格/CNY 货期 数量
50 μg ¥ 2,260 现货
100 μg ¥ 3,730 5日内发货
200 μg ¥ 6,130 5日内发货
500 μg ¥ 11,800 5日内发货
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产品目录号及名称: FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) (TMPY-06036)
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生物活性 Testing in progress
产品描述 FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P11362-7
别名 FGFR-1, FLG, CD331, HH2, FLT2, KAL2, FGFBR, HBGFR, CEK, HRTFDS, fibroblast growth factor receptor 1, OGD, FGFR1 α (IIIc), N-SAM, bFGF-R-1, FLT-2, BFGFR
蛋白构建 The Human FGFR1 alpha (IIIb) (NP_056934.2) (Met1-Lys310 and Ala359-Glu374 linked by FGFR1 IIIb Ig domain (AAB19502.1) (His1-Pro47)) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE.

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分子量 40.5 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ,idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR 1 FGFR-1 FLG CD331 HH2 CD 331 FLT2 KAL2 FGFBR HBGFR KAL 2 KAL-2 CD-331 HH-2 FGFR1 CEK HRTFDS fibroblast growth factor receptor 1 OGD FLT 2 FGFR1 α (IIIc) N-SAM bFGF-R-1 FLT-2 BFGFR HH 2 recombinant recombinant-proteins proteins protein

 

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