购物车

您的购物车当前为空

5-Fluorouridine

Name: 5-Fluorouridine
Brand: TargetMol
SKU: T1349
Price: 207 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.85%

货号 T1349Cas号 316-46-1

别名 5-氟尿嘧啶核苷

5-Fluorouridine 是一种 5-fluorouracil 的代谢物，具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用，其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。

为众多的药物研发团队赋能，

让新药发现更简单！

5-Fluorouridine

一键复制产品信息

很棒

纯度: 99.85%

货号 T1349 别名 5-氟尿嘧啶核苷Cas号 316-46-1

规格	价格	库存
50 mg	¥ 265	现货
100 mg	¥ 413	现货
200 mg	¥ 588	现货
500 mg	¥ 980	现货
1 mL x 10 mM (in DMSO)	¥ 207	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.85%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

5-Fluorouridine AI Summary

5-Fluorouridine exhibits a broad spectrum of potent bioactivities, particularly related to its antitumor properties. It shows strong cytotoxic effects against various cancer cell lines, including L1210 mouse leukemia cells (ID50 of 0.0024 uM) and other cell lines like MOLT-3, U-937, IM-9, and K-562, with IC50 values typically below 0.01 μg/mL. The compound specifically demonstrates powerful inhibitory activities against stomach and colon tumor cell lines, with IC50 values ranging from 5.4nM to 73.0nM. In in vivo models, 5-Fluorouridine prolongs the survival of mice inoculated with leukemia cells and shows dose-dependent effects on weight change and lifespan. Additionally, 5-Fluorouridine inhibits the growth of Mycobacterium tuberculosis by targeting thymidine monophosphate kinase (TMPK), with a Ki value of 521,000 nM, and exhibits competitive inhibition against bovine pancreatic RNase A, with a Ki value of 33600.0 nM. It also displays cytostatic activity in mouse and human leukemia cells, including those deficient in deoxythymidine kinase, and shows altered activity in the presence of different nucleosides and nucleobases, particularly uracil. Further evaluations reveal that 5-Fluorouridine has significant inhibitory effects against various cell lines, including leukemia, renal, lung, colon, melanoma, and ovarian, and has demonstrated efficacy in inhibiting viral activities against Hepatitis C, Lassa Virus, and Marburg Virus. It also inhibits the Menin-MLL interaction, hemoglobin beta chain splicing, and DNA re-replication, highlighting its potential in cancer therapeutic applications and beyond..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

别名

5-氟尿嘧啶核苷

化学信息

分子量	262.19
分子式	C₉H₁₁FN₂O₆
CAS No.	316-46-1
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(F)=C2
密度	1.77g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (953.51 mM), Sonication is recommended.

体内实验配方

5% DMSO+95% Saline: 1.25 mg/mL (4.77 mM), Solution.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8140 mL	19.0701 mL	38.1403 mL	190.7014 mL
5 mM	0.7628 mL	3.8140 mL	7.6281 mL	38.1403 mL
10 mM	0.3814 mL	1.9070 mL	3.8140 mL	19.0701 mL
20 mM	0.1907 mL	0.9535 mL	1.9070 mL	9.5351 mL
50 mM	0.0763 mL	0.3814 mL	0.7628 mL	3.8140 mL
100 mM	0.0381 mL	0.1907 mL	0.3814 mL	1.9070 mL