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3-MATIDA

Name: 3-MATIDA
Brand: TargetMol
SKU: T3486
Price: 173 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.96%

货号 T3486Cas号 518357-51-2

3-MATIDA 是一种有效的 mGluR-1 拮抗剂（IC50：6.3 μM，大鼠 mGluR-1a）。显示出 ≥ 40 倍于其他受体的选择性：mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。

为众多的药物研发团队赋能，

让新药发现更简单！

3-MATIDA

一键复制产品信息

很棒

纯度: 99.96%

货号 T3486Cas号 518357-51-2

规格	价格	库存
1 mg	¥ 173	现货
5 mg	¥ 428	现货
10 mg	¥ 696	现货
25 mg	¥ 1,410	现货
50 mg	¥ 2,320	现货
100 mg	¥ 3,310	现货
200 mg	¥ 4,630	现货
1 mL x 10 mM (in DMSO)	¥ 428	现货

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实验操作小课堂

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纯度: 99.96%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

3-MATIDA AI Summary

3-MATIDA exhibits diverse bioactivities, functioning as an inhibitor in various biological assays. It shows significant potency in inhibiting Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 28183.8 nM, 15-human lipoxygenase (15-hLO) with an IC50 of 39810.7 nM, 15-human lipoxygenase 2 (15-hLO-2) with an IC50 of 7943.3 nM, and blocking Tau fibril formation and Thioflavin T binding at 39810.7 nM. Notably, it has antiviral properties against SARS-CoV-2, demonstrated by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 3.65% at 10 μM concentration after 48 hours, and in VERO-6 cells with -0.25% inhibition under similar conditions. Additionally, 3-MATIDA acts as a SARS-CoV-2 3CL-Pro protease inhibitor, achieving 30.82% inhibition at 20 μM concentration in a FRET-based assay. It also inhibits human HDAC6 enzyme activity, although the inhibition is relatively low, with percentages of -15.65% using a commercial peptide substrate and -5.27% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
靶点活性	NMDA:250 μM, mGluR4:> 300 μM, mGluR2:> 300 μM, mGluR1:6.3 μM, mGluR5:> 300 μM, GluR(AMPA):250 μM

化学信息

分子量	215.23
分子式	C₈H₉NO₄S
CAS No.	518357-51-2
Smiles	C(C(O)=O)(N)C=1SC(C(O)=O)=CC1C
密度	1.542g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 2.16 mg/mL (10.04 mM), Sonication is recommended.

1eq. NaOH: 50 mM, Sonication is recommended.

溶液配制表

DMSO/1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	4.6462 mL	23.2310 mL	46.4619 mL	232.3096 mL
5 mM	0.9292 mL	4.6462 mL	9.2924 mL	46.4619 mL
10 mM	0.4646 mL	2.3231 mL	4.6462 mL	23.2310 mL

1eq. NaOH

	1mg	5mg	10mg	50mg
20 mM	0.2323 mL	1.1615 mL	2.3231 mL	11.6155 mL
50 mM	0.0929 mL	0.4646 mL	0.9292 mL	4.6462 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。