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(S)-ATPO

Name: (S)-ATPO
Brand: TargetMol
SKU: T3473
Price: 221 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.41%

货号 T3473Cas号 252930-37-3

别名 ATPO

(S)-ATPO 是 GluR1-4 (AMPA-preferring) 受体的竞争性拮抗剂。

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(S)-ATPO

一键复制产品信息

很棒

纯度: 99.41%

货号 T3473 别名 ATPOCas号 252930-37-3

(S)-ATPO 是 GluR1-4 (AMPA-preferring) 受体的竞争性拮抗剂。

规格	价格	库存
1 mg	¥ 221	现货
5 mg	¥ 581	现货
10 mg	¥ 918	现货
25 mg	¥ 1,750	现货
50 mg	¥ 2,570	现货
100 mg	¥ 3,690	现货
1 mL x 10 mM (in DMSO)	¥ 586	现货

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产品介绍

(S)-ATPO AI Summary

(S)-ATPO shows diverse bioactivity across multiple targets. It functions as an inhibitor of the Ionotropic glutamate receptor AMPA, demonstrating IC50 values of 35,000 nM for [3H]AMPA binding and 5,700 nM for [3H]CNQX binding. It also inhibits AMPA-induced electrophysiological responses in rat cortical slices with an IC50 value of 28,000 nM, but does not significantly inhibit [3H]CPP binding to the NMDA receptor or [3H]KAIN binding to the Ionotropic glutamate receptor kainate (IC50 > 100,000 nM). Additionally, (S)-ATPO inhibits several enzymes and pathways: Cruzain (158.5 nM), Bloom's syndrome helicase (BLM) (79.4 nM), Histone Lysine Methyltransferase G9a in various assays (50,118.7 nM, 8,912.5 nM, 5,323.3 nM), Pin1 (37,933.0 nM), and Human Flap endonuclease 1 (FEN1) (8,436.8 nM). It also inhibits Plasmodium falciparum (17,782.8 nM), Marburg Virus binding/entry (16,353.5 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) (50,118.7 nM). Moreover, it enhances Arylsulfatase A (ASA1) (4,256.2 nM and 67.5 nM in different assays) and identifies Gametocytocidal compounds (6,309.6 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
别名	ATPO

化学信息

分子量	322.25
分子式	C₁₁H₁₉N₂O₇P
CAS No.	252930-37-3
Smiles	CC(C)(C)c1onc(OCP(O)(O)=O)c1C[C@H](N)C(O)=O
密度	1.443 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 3.23 mg/mL (10.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1032 mL	15.5159 mL	31.0318 mL	155.1590 mL
5 mM	0.6206 mL	3.1032 mL	6.2064 mL	31.0318 mL
10 mM	0.3103 mL	1.5516 mL	3.1032 mL	15.5159 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。