Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.

Cat. No.	Product Name	CAS No.	Purity
T67874	PFKFB3-IN-2 化合物PFKFB3-IN-2	794552-84-4	98%
T67874	PFKFB3-IN-2是一种6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3)抑制剂。在体内，对PFKFB3进行反义治疗可降低肿瘤生长速度。
T60048	WAY-640509 化合物WAY-640509	851185-20-1	98%
T60048	WAY-640509是一种葡糖脑苷酶抑制剂。
T8990	ML266 化合物ML266	1462267-08-8	98%
T8990	ML266 是葡萄糖脑苷脂酶 (GCase) 分子伴侣， IC50值为 2.5 µM。ML266与 GCase 结合并将其转运至溶酶体，恢复 GCase 酶的活性。ML266 不会抑制 GCase 的活性。ML266 具有研究戈谢病的潜力。
T14212	AMG-1694 化合物AMG-1694	1361217-07-3	98%
T14212	AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白（GK-GKRP）干扰物，能促进 GK-GKRP 复合物的解离，其 IC50 值为 7 nM，从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常，并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GK...
T3386	Kaempferitrin 山奈苷	482-38-2	98%
T3386	Kaempferitrin 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
TN5192	Tuberosin 化合物 TN5192	41347-45-9	98%
TN5192	Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
TN5090	Tachioside 化合物 TN5090	109194-60-7	98%
TN5090	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
TN4793	Pinoresinol diacetate 化合物 TN4793	32971-25-8	98%
TN4793	Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
T10751	Cefetrizole 头孢三唑	65307-12-2	98%
T10751	Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TN5094	Tangshenoside I 党参苷 I	117278-74-7	98%
TN5094	Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
TN3745	Cyclomusalenone 化合物 TN3745	30452-60-9	98%
TN3745	Cyclomusalenone is a potent α-glucosidase inhibitor.
T11749	KDM4-IN-2 化合物 T11749	2369607-62-3	98%
T11749	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
TN4174	Guajadial 化合物 TN4174	959860-49-2	98%
TN4174	Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
T16480	PF-04991532 化合物 T16480	1215197-37-7	98%
T16480	PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T6759	AP-III-a4 化合物AP-III-a4	1177827-73-4	98%
T6759	AP-III-a4 是第一个非底物类似物，可直接与烯醇酶结合，IC50=0.576 uM，可阻碍体内癌细胞转移。
T64320	ML251 化合物ML251	1486482-16-9	98%
T64320	ML251 是一种有效的新型纳摩尔 T. brucei 和 T. cruzi 磷酸果糖激酶抑制剂，对 T. brucei PFK 和 T. cruzi PFK 的 IC50值为 0.37和 0.13 μM，可研究寄生虫。
T2455	PFK-015 化合物PFK-015	4382-63-2	98%
T2455	PFK015是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。
T22223	3PO 化合物3PO	18550-98-6	98%
T22223	3PO 是一种 PFKFB3 的小分子抑制剂，IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖，IC50在1.4到24 μM 之间。它抑制葡萄糖摄取，并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
T3312	AM-2394 化合物AM2394	1442684-77-6	98%
T3312	AM2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK)，EC50=60 nM。
T26712	AZD-1656 化合物AZD-1656	919783-22-5	98%
T26712	AZD1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。