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Glucokinase

Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T67874 PFKFB3-IN-2
化合物PFKFB3-IN-2
794552-84-4 98%
PFKFB3-IN-2是一种6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3)抑制剂。在体内,对PFKFB3进行反义治疗可降低肿瘤生长速度。
T60048 WAY-640509
化合物WAY-640509
851185-20-1 98%
WAY-640509是一种葡糖脑苷酶抑制剂。
T8990 ML266
化合物ML266
1462267-08-8 98%
ML266 是葡萄糖脑苷脂酶 (GCase) 分子伴侣, IC50值为 2.5 µM。ML266与 GCase 结合并将其转运至溶酶体,恢复 GCase 酶的活性。ML266 不会抑制 GCase 的活性。ML266 具有研究戈谢病的潜力。
T14212 AMG-1694
化合物AMG-1694
1361217-07-3 98%
AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白(GK-GKRP)干扰物,能促进 GK-GKRP 复合物的解离,其 IC50 值为 7 nM,从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常,并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GK...
T3386 Kaempferitrin
山奈苷
482-38-2 98%
Kaempferitrin 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。
TN5192 Tuberosin
化合物 TN5192
41347-45-9 98%
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
TN5090 Tachioside
化合物 TN5090
109194-60-7 98%
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
TN4793 Pinoresinol diacetate
化合物 TN4793
32971-25-8 98%
Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
T10751 Cefetrizole
头孢三唑
65307-12-2 98%
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TN5094 Tangshenoside I
党参苷 I
117278-74-7 98%
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
TN3745 Cyclomusalenone
化合物 TN3745
30452-60-9 98%
Cyclomusalenone is a potent α-glucosidase inhibitor.
T11749 KDM4-IN-2
化合物 T11749
2369607-62-3 98%
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
TN4174 Guajadial
化合物 TN4174
959860-49-2 98%
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
T16480 PF-04991532
化合物 T16480
1215197-37-7 98%
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T6759 AP-III-a4
化合物AP-III-a4
1177827-73-4 98%
AP-III-a4 是第一个非底物类似物,可直接与烯醇酶结合,IC50=0.576 uM,可阻碍体内癌细胞转移。
T64320 ML251
化合物ML251 
1486482-16-9 98%
ML251 是一种有效的新型纳摩尔 T. brucei 和 T. cruzi 磷酸果糖激酶抑制剂,对 T. brucei PFK 和 T. cruzi PFK 的 IC50值为 0.37和 0.13 μM,可研究寄生虫。
T2455 PFK-015
化合物PFK-015
4382-63-2 98%
PFK015是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
T22223 3PO
化合物3PO
18550-98-6 98%
3PO 是一种 PFKFB3 的小分子抑制剂,IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖,IC50在1.4到24 μM 之间。它抑制葡萄糖摄取,并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
T3312 AM-2394
化合物AM2394
1442684-77-6 98%
AM2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK),EC50=60 nM。
T26712 AZD-1656
化合物AZD-1656
919783-22-5 98%
AZD1656 是口服有效的葡萄糖激酶选择性激活剂,EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
PFKFB3-IN-2
T67874
PFKFB3-IN-2是一种6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3)抑制剂。在体内,对PFKFB3进行反义治疗可降低肿瘤生长速度。
WAY-640509
T60048
WAY-640509是一种葡糖脑苷酶抑制剂。
ML266
T8990
ML266 是葡萄糖脑苷脂酶 (GCase) 分子伴侣, IC50值为 2.5 µM。ML266与 GCase 结合并将其转运至溶酶体,恢复 GCase 酶的活性。ML266 不会抑制 GCase 的活性。ML266 具有研究戈谢病的潜力。
AMG-1694
T14212
AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白(GK-GKRP)干扰物,能促进 GK-GKRP 复合物的解离,其 IC50 值为 7 nM,从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常,并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GK...
Kaempferitrin
T3386
Kaempferitrin 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。
Tuberosin
TN5192
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
Tachioside
TN5090
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
Pinoresinol diacetate
TN4793
Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
Cefetrizole
T10751
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
Tangshenoside I
TN5094
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
Cyclomusalenone
TN3745
Cyclomusalenone is a potent α-glucosidase inhibitor.
KDM4-IN-2
T11749
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
Guajadial
TN4174
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
PF-04991532
T16480
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
AP-III-a4
T6759
AP-III-a4 是第一个非底物类似物,可直接与烯醇酶结合,IC50=0.576 uM,可阻碍体内癌细胞转移。
ML251
T64320
ML251 是一种有效的新型纳摩尔 T. brucei 和 T. cruzi 磷酸果糖激酶抑制剂,对 T. brucei PFK 和 T. cruzi PFK 的 IC50值为 0.37和 0.13 μM,可研究寄生虫。
PFK-015
T2455
PFK015是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
3PO
T22223
3PO 是一种 PFKFB3 的小分子抑制剂,IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖,IC50在1.4到24 μM 之间。它抑制葡萄糖摄取,并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
AM-2394
T3312
AM2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK),EC50=60 nM。
AZD-1656
T26712
AZD1656 是口服有效的葡萄糖激酶选择性激活剂,EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
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