trap-3

Cl-amidine hydrochloride 是一种口服有效的PAD抑制剂，可阻断组蛋白3去亚胺化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。

TRAP-1 (XJZ-06-462) 作为一种p53转录激活剂，能够有效地在突变p53中触发p53靶基因的转录活性。在胰腺细胞系p53Y220C中，该化合物能迅速提高p21等p53靶基因的表达水平。此外，TRAP-1 在BxPC-3和A549细胞线中显示出抑制细胞增殖的效果，其半抑制浓度(IC50)分别为3.94和0.531 μM。该化合物还能促进肺癌细胞的自噬作用，并在氧化应激和细胞凋亡方面提供保护。

2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.