p-88

Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. It is a metabolite of Iloperidone.

GHP-88309 是一种口服有效的广谱抗副黏病毒 (paramyxoviruses) 剂，作用于病毒聚合酶 (viral polymerase)，干扰病毒 RNA 合成，并能够抑制呼吸道合胞病毒 (RSV)、麻疹病毒 (MeV) 和犬瘟热病毒 (CDV)，其EC50范围为0.06-1.2 μM。在小鼠模型中，GHP-88309 显示出抗感染活性。

SMP-88480为一类抗体-药物偶联物(Antibody-Drug Conjugates (ADCs))，在小鼠、猴与人血浆中展现出稳定性，并对卵巢癌、胃癌、乳腺癌显示出体内抗肿瘤活性。

Ziprasidone hydrochloride (CP-88059 hydrochloride) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。

Antibiotic LL-P880y 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124885，CAS号为 41206-21-7。

LL P880 beta is a fungal metabolite.

Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively.

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.

P-gp inhibitor 27 (Compound D2) 是一种 P-糖蛋白 (P-gp) 抑制剂，能够降低 P-gp 和 MRP1 的表达，增加 A2780 T 细胞中 Rh123 的积累，并扭转对 Paclitaxel (EC50为 88 nM) 和 Cisplatin 的多药耐药性。

HDAC-IN-88 (Compound HJ-9) 是一种HDAC抑制剂，能够抑制HDAC6、HDAC1、HDAC2、HDAC8和HDAC3，其IC50分别为0.226、1.103、2.308、3.255和3.864 μM。HDAC-IN-88 抑制癌细胞 HepG2、HCT116 和 MV4-11 的增殖，IC50依次为5.47、9.78 和 0.38 μM，并抑制HCT116的迁移，同时在G0 G1期阻滞细胞周期，在MV4-11中引发细胞凋亡 (apoptosis) 和自噬 (autophagy)。HDAC-IN-88 可降低ROS水平和线粒体膜电位，显示出抗疟活性，能够抑制恶性疟原虫P. falciparum3D7，EC50为165 nM。此外，HDAC-IN-88 具备抗血管生成活性。

CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1]. CC-90005 shows the exquisite selectivity of CC-90005, with IC50s for all other family members of >3 μM[1].CC-90005 is a moderate inhibitor of both CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes[1].CC-90005 inhibits IL-2 expression in LRS_WBC human PBMCs, with an IC50 of 0.15 μM[1].CC-90005 (1-10 μM; 24 h) inhibits T cell proliferation in PBMCs by 51% at 1 μM and 88% at 3 μM[1]. CC-90005 (3-30 mg kg; p.o. twice daily for 4 days) significantly reduces the popliteal lymph node (PLN) size in a model of chronic T cell activation[1].CC-90005 (100 mg kg; a single p.o.) significantly inhibits plasma and spleen IL-2 release by 51 and 54%, respectively[1].CC-90005 exhibits reasonable oral bioavailability (66 and 46%) and Cmax (1.18 and 1.2 μM) following oral administration (10 and 3 mg kg) in rat and dog, respectively[1].CC-90005 exhibits the mean residence time (0.52 and 2.0 h), CL (69.1 and 20.5 mL min kg) and Vss (2.11 and 2.44 L kg) following intravenous administration (2 and 1 mg kg) in rat and dog, respectively[1]. [1]. Papa P, et, al. Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005. J Med Chem. 2021 Aug 26;64(16):11886-11903.

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg kg) reduces tumor growth in an SW1990 mouse xenograft model. |1. Zhang, P., Li, X.-M., Wang, J.-N., et al. New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity. Phytochem. Lett. 11, 85-88 (2015).|2. Sun, W., Luan, S., Qi, C., et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun. Signal. 17(1), 111 (2019).

Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg ml.

Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物，展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫（IC50=0.408 μM）。在100 μM浓度时，Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内，以48.4 μM kg day剂量对伯氏疟原虫展示96.67%的抑制效果；在体外，其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌，MIC值为28.44 μM。

Lariciresinol p-coumarate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5438，CAS号为 864452-88-0。