oligomer

Anle138b 是一种毒性低，口服生物利用度高，血脑屏障通透性好的低聚物聚集抑调节剂，可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。

Oligomer-lipid 7C1 是一种电离脂质，由低分子量多胺与脂质反应生成。Oligomer-lipid 7C1 能有效结合 siRNA 形成纳米颗粒，并在非人灵长类动物的多个器官内皮细胞中引发 RNA 干扰。它能递送 siRNA 至内皮细胞，在小鼠模型中改善血管通透性、肺气肿、原发性肿瘤的生长和转移的内皮功能。

7BIO 是靛玉红的衍生物，抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。

hAChE-IN-1（Compound 24）作为一种有效的hAChE抑制剂，显示出1.09 μM的IC50值。进一步，在细胞tau FRET实验中，该化合物对tau寡聚具有抑制作用，其EC50为2.71 μM。

IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。

Chitosan oligosaccharide (COS) 是 β-(1→4)-连接的 D-氨基葡萄糖的寡聚体，Chitosan oligosaccharide可激活 AMPK ，抑制NF-κB 和 MAPK在内的炎症信号通路。

Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物，主要用作化妆品的香料和食品增味剂，也可作 PPAR-α激动剂。

PQM130是一种魏罗酮-多奈哌齐杂化化合物，能透过大脑。PQM130是多靶点的候选药物，可用于Aβ1-42低聚物引起的神经毒性，还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。

ALZ-801 是一种可口服的小分子 β-淀粉样蛋白抗寡聚体和聚集抑制剂，是曲米酸的缬氨酸偶联前药，与母体化合物相比，具有显著改善的 PK 特性和胃肠道耐受性。它是治疗阿尔茨海默病的先进且显著改善的候选药物。

Antitumor agent-196 (Compound 6a (β, β, β)) 是一种青蒿素基础的低聚物，具有抗癌的特性，对 MCF-7 乳腺癌细胞(IC50 = 90 nM)表现出活性。它可通过调节 Bax-caspase 3 信号通路来诱导细胞凋亡 (Apoptosis)，并通过调控关键分子(如 GPX4)引发铁死亡 (Ferroptosis)。Antitumor agent-196 在癌症治疗研究中表现出应用潜力。

α-Synucleininhibitor 11 (compound 1) 是一种可抑制 α-突触核蛋白 (α-syn) 寡聚体形成的选择性抑制剂。它不抑制 tau 4R（同工型 0N4R、2N4R）或 p-tau（同工型 1N4R），适用于帕金森病 (PD) 研究。

Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to other organic compounds.

GT-02216可以异位结合GCase并增强其活性。在主要人类成纤维细胞中，GT-02216提高了GCase的活性。GT-02216减少了突变GBA1成纤维细胞中的Tau积累。GT-02216在大鼠模型中保护面临Tau低聚物挑战的海马初级神经元。

SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo.

RS-0406 is a new type of β-flakes blocker, which can reverse amyloid β-induced cytotoxicity and long-term enhanced damage in vitro, and inhibit amyloid-oligomer-induced behavior deterioration in vivo.

D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].

Chitotetraose tetrahydrochloride is a short-chain chitin oligomer derived from arbuscular mycorrhizal (AM) fungi. This compound effectively activates the conserved symbiosis signaling pathway (CSSP) in actinorhizal plant species.

BMS-984923 是可口服且具有血脑屏障透过性的 mGluR5 沉默异构调节剂，抑制β-淀粉样蛋白寡聚体诱导的异常突触信号传导，可用于研究阿尔茨海默症。

D-Tetramannuronic acid, an alginate oligomer, is derived from marine brown algae and certain Gram negative bacteria. It serves as a valuable compound for pain and vascular dementia research[4].

D-Pentamannuronic acid is an alginate oligomer, synthesized by marine brown algae and a select group of Gram-negative bacteria. This chemical compound is valuable for research related to pain and vascular dementia[4].

D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4].

D-Heptamannuronic acid, an alginate oligomer, is derived from marine brown algae and a select group of Gram-negative bacteria. This compound serves as a valuable research tool in the study of pain and vascular dementia[4].

D-Octamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram-negative bacteria. It is research-oriented for the study of pain and vascular dementia [4].

2,2':5',2''-Terthiophene (Trithiophene) 是杂环噻吩的低聚物，可用作有机合成的砌块 。