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NL-1 是一种mitoNEET 抑制剂，具有抗白血病作用。它抑制 REH 和 REH Ara-C 细胞生长，IC50分别为 47.35 µM 和 56.26 µM。

Phenylbutazone (Butazolidine) 是是非甾体类抗炎药，前列腺素 H 合酶过氧化物酶的还原辅助因子，可诱导肌肉盲样蛋白 1 表达，有用于强直性脊柱炎的研究潜力。

Reparixin (Repertaxin) 是两种 CXCL8 受体 CXCR1 2 的强效抑制剂，它对 CXCR2 介导的细胞迁移具有微弱的抑制作用 ，IC50为 100 nM。它强烈阻断 CXCR1 介导的趋化性，IC50为 1 nM。

(-)-Gomisin L1 induces G2 M arrest and apoptosis in human ovarian cancer cells.

S1b3inL1 是 SARS-CoV-2 刺突蛋白的大环肽抑制剂，能够高亲和力结合刺突蛋白的保守位点，从而抑制多种 SARS-CoV-2 变异株的感染并显示抗病毒活性。

NL13作为一种Polo样激酶4 (PLK4) 抑制剂，具有2.32 μM的IC50值。在抑制前列腺癌细胞线PC3和DU145方面，其IC50值分别为3.51 μM和2.53 μM。该化合物能够引起AKT信号通路的失活，并通过下调CCNB1 CDK1，导致G2 M细胞周期阻滞。同时，NL13通过caspase-9 caspase-3切割，触发细胞凋亡（apoptosis）。此外，NL13在小鼠模型中已证实能有效抑制前列腺癌肿瘤的生长。

AM92016 is a specific blocker of the time dependent delayed rectifier potassium current. AM92016 does not show any β-adrenoceptor blocking activity.

ONL-1204 is a small molecule, CD95 antigen inhibitor (Fas inhibitor) being developed by ONL Therapeutics for the treatment of retinal detachment.

NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.

GNF7156 is a potent and selective DYRK1A inhibitor.