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Anti-DNase I Antibody (4N202) 是一种 Rabbit 抗体,靶向 DNase I。Anti-DNase I Antibody (4N202) 可用于 ELISA。
Anti-DNase I Antibody (4N202) 是一种 Rabbit 抗体,靶向 DNase I。Anti-DNase I Antibody (4N202) 可用于 ELISA。
产品描述 | Anti-DNase I Antibody (4N202) is a Rabbit antibody targeting DNase I. Anti-DNase I Antibody (4N202) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 4N202 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human DNase1 / Deoxyribonuclease I / DNL1 (rh DNase1 / Deoxyribonuclease I / DNL1; TMPY-03855; P24855; Met1-Lys282). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. |
偶联 | Unconjugated |
免疫原 | Recombinant Human DNase1 / Deoxyribonuclease I / DNL1 Protein (TMPY-03855) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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