f-actin

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Defactinib (VS-6063) 是一种 FAK 的第二代抑制剂，抑制 FAK 在 Tyr397 位点磷酸化。Defactinib 具有潜在抗肿瘤活性。

Surfactin 是一种有效的环状脂肽生物表面活性剂，可介导单价和二价阳离子（如钙）穿过脂质双层膜的通量，具有抗菌、抗真菌、抗支原体和溶血作用。

Surfactin C2 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125603，CAS号为 171039-18-2。

Surfactin B1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125988，CAS号为 136109-79-0。

Defactinib hydrochloride (PF 04554878 hydrochloride) (VS-6063 hydrochloride; PF 04554878 hydrochloride) 是一种新型 FAK 抑制剂，抑制 FAK 在 Tyr397 位点磷酸化，这种作用具有时间和剂量依赖性。

Defactinib analogue-1 (Compound 7) 作为一种靶向Fak的配体，可用于PROTAC FAK degrader 1的合成。

Arthrofactin is a lipopeptide biosurfactant.

Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。

Phalloidin 是一种在鹅膏菌中发现的双环七肽，参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长，可用于标记脑血管。

E0924G 是一种具有口服活性的PPARδ激活剂，其EC50为2.82 μM。它能够上调骨保护素 (OPG) 的表达，EC50为0.29 μM。E0924G 能够减少RANKL诱导的破骨细胞分化，并抑制RAW264.7巨噬细胞中的F-肌动蛋白环形成。此外，E0924G 还可以调节卵巢切除 (OVX) 和年龄相关性骨质疏松症模型中的骨密度和骨质流失。

Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.

Pfn1-IN-C2, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.

Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer. Sinoporphyrin sodium is als

FIPI (5-Fluoro-2-indolyl deschlorohalopemide) 是 halopemide 的衍生物，抑制PLD1和PLD2，IC50值分别为 25 nM 和 20 nM。它防止 PLD 调节 F-肌动蛋白细胞骨架重组、细胞扩散和趋化性。

Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. It can be used to localize actin filaments in living or fixed cells, as well as for visualizing individual actin filaments in vitro.

Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.

Phalloidin-FITC is a green fluorescent cytoskeleton stain. Binds and labels F-actin. For most fluorescent imaging applications, cells should be fixed and permeablilized. Excitation/emission maxima λ ~496/516 nm.

Phalloidin-Janelia Fluor®646 is a red fluorescent F-actin probe. Phalloidin-Janelia Fluor®646 is composed of the F-actin probe, Phalloidin, conjugated to Janelia Fluor®646. It is suitable for use in confocal and super-resolution microscopy techniques such as dSTORM. Excitation emission maximum λ = 646 664 nm.

ROCK-IN-4 是 ROCK 的有效抑制剂，可维持 NO 释放能力。ROCK-IN-4 能够可逆地解聚 F-肌动蛋白，并阻碍人小梁网 (HTM) 细胞的线粒体呼吸。ROCK-IN-4 能够用于研究青光眼或高眼压。

DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to serve as a chemoprevention drug for patients with metastatic melanoma.

Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2 M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。

8-CPT-2'-O-Me-cAMP（250 µM；1 h）可引导 Rap1 激活，进而在视网膜色素上皮细胞中促进连接蛋白及皮质 F-肌动蛋白的聚集。

Body Protection Compound 157 (BPC 157) is a pentadecapeptide derived from BPC, identified in gastric juice, exhibiting diverse biological activities. At 2 µg ml, BPC 157 enhances primary rat tendon fibroblast cell migration and F-actin formation. Furthermore, doses of 0.01 and 10 µg kg, intraperitoneally (i.p.), mitigate paw swelling, bone erosion, and mononuclear cell infiltration in the joints of rats with rheumatoid arthritis induced by complete Freund's adjuvant (CFA). It also diminishes gastric ulcer size in rats caused by indomethacin, aspirin, or diclofenac at these doses. Additionally, BPC 157 reduces catalepsy duration and tremor severity in a mouse model of Parkinson's disease triggered by MPTP.