diarrhea

Rifaximin 是一种胃肠道选择性抗生素，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，抑制细菌 RNA 合成。与革兰氏阴性菌（MIC：8-50 毫克 毫升）相比，它对革兰氏阳性菌株（MIC：0.03-5 毫克 毫升）的敏感性更高。

BVDV-IN-1 是一种牛病毒性腹泻病毒 (BVDV) 的非核苷抑制剂 (NNI)，EC50 为 1.8 μM。它直接与 BVDV RdRp 的疏水口袋结合，对耐 NNI 氨基硫脲 (TSC) 的 BVDV 具有抗病毒活性。

Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。

GS-6620 PM 是GS-6620的衍生物。GS-6620是一种口服的抗丙型肝炎病毒聚合酶抑制剂，是一种新型强效的C-核苷腺嘌呤类似物单磷酸酯原药。GS-6620对其他病毒的活性有限，对密切相关的牛病毒性腹泻病毒仅保持部分活性（EC50，1.5μM）。

SLC26A3-IN-1 是一种阴离子交换蛋白 SLC26A3 的抑制剂 ，IC50值为340 nM。SLC26A3 属于溶质载体 (SLC) 蛋白，是 SLC26 家族成员之一。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调，参与氯化物和草酸盐的肠道吸收且与氯离子丢失性腹泻有关。

Aligeron 是一种非选择性的prostaglandin (PG)拮抗剂，对PGF2α和PGE2诱导的猫血压下降有抑制作用，可用于抑制PGF2α诱导的小鼠腹泻和PGE2诱导的大鼠爪水肿。Aligeron 对血管并发症具有抗氧化保护作用。

Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。

Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。

Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂，具有窄谱活性。它选择性地根除致病性艰难梭菌，对构成正常健康肠道菌群的多种细菌影响很小。

Bismuth Subsalicylate (Bismuth subsalicylat) 是口服抗酸和止泻试剂。它能够抑制体内前列腺素合成，抑制胃和肠道黏膜炎症反应。它广泛用于研究腹泻疾病，如恶心、消化不良、腹泻等。

Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂，可有效缓解疼痛、腹泻和肠道不适。

Isolicoflavonol 以可逆和混合的方式抑制人羧酸酯酶2介导的荧光素二乙酸酯水解， Ki 小于1.0 μM。

Pinaverium-d4 Bromide (Mixture of Diastereomers) 是 Pinaverium Bromide 的氘代化合物。Pinaverium Bromide 的 CAS 号为 53251-94-8。Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂，可有效缓解疼痛、腹泻和肠道不适。

Aminopentamide（亦称Dimevamide）是一种抗胆碱能化合物，主要用于治疗犬猫的呕吐和腹泻，起效作用于平滑肌抗痉挛。

Alosetron-13C-d3 是 Alosetron 的 13C 和氘代化合物。Alosetron 的 CAS 号为 122852-42-0。

Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.

NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, and NHC-TP reaches up to 71.12 pM after 8 hours[1].NHC-triphosphate triammonium (NHC-TP) (5-40 μM) absence leads to full-length polymerization products, it can be a weak alternative substrate. In addition, incorporation of NHC-TP instead of CTP increases the molecular weight of the polymerization product by 16 (one extra oxygen) for each event and an obvious electrophoretic shift is observed in cell-free HCV NS5B polymerization reactions[1].Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP) can be observed, while NHC-triphosphate triammonium remains the most abundant metabolite[2].NHC-triphosphate triammonium (NHC-TP) metabolite may directly target the viral polymerase and behave as a nonobligate chain terminator. It plays a prominent role in inhibiting early negative-strand RNA synthesis, either through chain termination or mutagenesis, which may in turn interfere with correct replicase complex formation. [1]. Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54. [2]. Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance.

hCES2-IN-1（Compound 24）是一种选择性的hCES2可逆抑制剂，其IC50值为6.72 μM。该化合物能够减少活细胞中hCES2的表达量，并且能有效抵抗由Irinotecan引起的迟发性腹泻以及DSS诱发的溃疡性结肠炎。

Nummularine B is a cyclopeptide alkaloid. It has antiviral activity against the porcine epidemic diarrhea virus. It also has potent inhibitory effects on PEDV replication.

Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。

Methysergide is used for prophylaxis of migraine headaches/cluster headaches but is no longer recommended due to retropulmonary/retroperitoneal fibrosis. It may also be used in the treatment of serotonin syndrome. It is also used in carcinoid syndrome to

DB772 是一种广谱抗病毒活性，抑制牛病毒性腹泻病毒(BVDV)、朊病毒活性、边界病病毒(BDV)、HoBi病毒、叉角病毒和Bungowannah病毒。

Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the