adar

Adarotene (ST1926) 是一种细胞凋亡诱导剂，通过产生 DNA 损伤，来阻止人类肿瘤细胞的增殖。

Piadar is a new antimycotic containing the antifungal agent siccanin.

Adarigiline is a monoamine oxidase B inhibitor.

Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.

Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis, thereby slowing the progression of experimental human melanoma. It may be employed in research concerning COPD, asthma, and melanoma.

Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。

Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) 是一种甲氧基腺苷衍生物，从加勒比海绵 Tectitethya crypta 中分离得到。已经证明其具有多种生物活性，如抗炎活性，缓解疼痛和血管舒张特性。它能够抑制小鼠淋巴瘤细胞的增殖。

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a Nucleoside, fluoro-modified nucleoside; Arabino-nucleosidde.

FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label cells and track DNA synthesis.

Nucleoside Derivatives - Fluoro-modified nucleosides, Arabino-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; Anticancer agent; Impurity C of Clofarabine

1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.

8-Azanebularine是通过将C6位的氨基替换为氢的化合物，能在高浓度(IC50=15 mM)下抑制ADAR2活性。该化合物在人类ADAR2识别的RNA结构中插入，展示出高亲和力(KD=2 nM)。因此，8-Azanebularine可应用于研究ADAR催化的RNA编辑过程。

Elacytarabine (M7594 0037) 是核苷类似物阿糖胞苷的一种脂质缀合衍生物。Elacytarabine (M7594 0037) (CP 4055) 是一种抗肿瘤药物，在实体瘤中具有细胞毒性。

Nefazodone(奈法唑酮)是一种口服类抗抑郁药物，是突触后5-HT 2A受体和5-HT 2C受体的拮抗剂，还能够抑制去甲肾上腺素、多巴胺、血清素的再摄取（SNDRI）。

Fludarabine-Cl 抑制 RNA 腺苷脱氨酶1 (ADAR1) ，它可用于预防和/或治疗与肿瘤或癌症相关的疾病。

Hexa-D-arginine 是稳定的furin 抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

8-Azaadenosine 是 ADAR1抑制剂和是 A-to-I 编辑抑制剂。它可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。

Nucleoside Derivatives - Fluoro-modified nucleosides, Arabino-nucleosides, 6-Modified purine nucleosides, 2'-Modified nucleosides

Fluoro-modified nucleoside; Iso-guanosine derivative; Arabino-nucleoside

Fluoro-modified nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside

Fluoro-modified nucleoside; Azido-nucleoside; Arabino-nucleoside

2'-Deoxy-2'-fluoro-N3-(4-nitrobenzyl)-beta-D-arabinouridine is a Nucleoside Derivative - Fluoro-modified nucleoside,Arabino-nucleoside, 2'-Modified nucleoside.

2'-Deoxy-2'-fluoro-N3-[(pyridin-2-yl)methyl]-beta-D-arabinouridine is a Nucleoside Derivative - Fluoro-modified nucleoside,Arabino-nucleoside, 2'-Modified nucleoside.