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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ADAR1 Polyclonal Antibody

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货号 TMAB-02310

Anti-ADAR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADAR1。Anti-ADAR1 Polyclonal Antibody 可用于 WB,FCM。

Anti-ADAR1 Polyclonal Antibody

Anti-ADAR1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-02310

Anti-ADAR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADAR1。Anti-ADAR1 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-ADAR1 Polyclonal Antibody is a Rabbit antibody targeting ADAR1. Anti-ADAR1 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5: Nucleus, nucleolus.
组织特异性Ubiquitously expressed, highest levels were found in brain and lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DRADA
抗原种属
Human
基因名称
ADAR
基因ID
103
蛋白名称
Double-stranded RNA-specific adenosine deaminase
Uniprot ID
P55265
功能
Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
化学信息
分子量Theoretical: 135 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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