Tulobuterol hydrochloride

Name: Tulobuterol hydrochloride
Brand: TargetMol
SKU: T3277
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.24%

货号 T3277Cas号 56776-01-3

别名 盐酸妥布特罗, Hokunalin, Berachin

Tulobuterol hydrochloride (Hokunalin) 是一种长效的 β2肾上腺素受体激动剂，可减少慢性阻塞性肺疾病和支气管哮喘的发作频率。它也是一种拟交感神经药，用作透皮贴剂，可增加正常的横膈膜肌肉力量。它抑制鼻病毒复制并调节气道炎症。

Tulobuterol hydrochloride

一键复制产品信息

很棒

纯度: 99.24%

货号 T3277 别名 盐酸妥布特罗, Hokunalin, BerachinCas号 56776-01-3

规格	价格	库存
25 mg	¥ 166	现货
50 mg	¥ 228	现货
100 mg	¥ 328	现货
500 mg	¥ 868	现货
1 g	¥ 1,280	现货
1 mL x 10 mM (in DMSO)	¥ 253	现货

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纯度: >99.99%

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产品介绍

Tulobuterol hydrochloride AI Summary

Tulobuterol hydrochloride exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 2,819.8 nM to 17,782.8 nM, effectively inhibiting the proliferation of lines such as Dd2, 3D7, W2, GB4, 7G8, D10, and HB3. Additionally, it demonstrates potent activity as an inhibitor of Bloom's syndrome helicase (BLM) with a potency of 281.8 nM, and inhibitory effects on the malarial parasite plastid and Marburg Virus entry into cells with potencies around 8,912.5 nM. It also shows activity as a GLP-1 Receptor Agonist with a potency of 29.1 nM. In terms of antiviral properties, Tulobuterol hydrochloride exhibits moderate activity in inhibiting cell viability of Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), showing inhibition indices of 0.6288 and 0.251 at MOI 0.002. It inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 µM after 48 hours, with an inhibition of -2.91%. Furthermore, it displays an inhibition percentage of 9.32% in the assay measuring SARS-CoV-2 3CL-Pro protease inhibition at 20 µM, indicating potential bioactivity in targeting the protease enzyme critical for viral replication. It also inhibits cytotoxicity of VERO-6 cells with an observed inhibition of 0.05% at 10 µM concentration following 48 hours exposure to 0.01 MOI SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tulobuterol hydrochloride (Hokunalin) is a long-acting beta2-adrenergic receptor agonist.
别名	盐酸妥布特罗, Hokunalin, Berachin

化学信息

分子量	264.19
分子式	C₁₂H₁₉Cl₂NO
CAS No.	56776-01-3
Smiles	CC(C)(C)NCC(c1ccccc1Cl)O.Cl
密度	1.098 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (227.11 mM), Sonication is recommended.

H2O: 200.6 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.57 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7852 mL	18.9258 mL	37.8515 mL	189.2577 mL
5 mM	0.7570 mL	3.7852 mL	7.5703 mL	37.8515 mL
10 mM	0.3785 mL	1.8926 mL	3.7852 mL	18.9258 mL
20 mM	0.1893 mL	0.9463 mL	1.8926 mL	9.4629 mL
50 mM	0.0757 mL	0.3785 mL	0.7570 mL	3.7852 mL
100 mM	0.0379 mL	0.1893 mL	0.3785 mL	1.8926 mL