colchicine

Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。

Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。

3-Demethylcolchicine 是一种从金莲花中分离得到的天然产物，对纯化的牛脑微管蛋白的聚合有抑制作用。

Tubulin inhibitor 24 是一种 tubulin 抑制剂，可以抑制微管蛋白聚合，以浓度依赖性方式诱导细胞周期停滞在 G2 M 期， 具有抗肿瘤活性且无明显毒性。

Colchicine, deacetamido-5,6-didehydro- is a biochemical.

Colchicine, N-deacetyl-10-thio- is a biochemical.

Colchicine-d6 是 Colchicine 的氘代化合物。Colchicine 的 CAS 号为 64-86-8。Colchicine 是微管蛋白抑制剂和微管干扰剂，通过与微管蛋白结合来阻断微管的聚合，IC50值为 3 nM。它还是α3甘氨酸受体的竞争性拮抗剂。

Crolibulin (EPC2407) 是一种微管蛋白聚合抑制剂，具有诱导凋亡和抑制细胞生长的作用。它有抗肿瘤活性，还具有心血管毒性和神经毒性。

gamma-Lumicolchicine is three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actions.

3-Demethylthiocolchicine, 一种Colchicine衍生物, 显示出强大的抗肿瘤活性。与Colchicine相比, 该化合物在阻止酪蛋白诱导的淀粉样变性、微管结合和抗炎作用方面表现出相似的效能，但其毒性更低。

Lumicolchicine is a bioactive chemical.

Deacetylisocolchicine is a biochemical.

4-Formylcolchicine 为一有效抗癌化合物，展示对 A549、HT-29、HCT116 细胞具有细胞毒性活性，其 IC50 值分别为 1.007 µM、0.128 µM、0.054 µM。

Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https: www.medkoo.com page naming) for ease of communication.

Deacetylthiocolchicine hydrochloride is a biochemical.

Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂，可在 G2 M 期诱导细胞周期停滞和细胞凋亡。 它 与微管结合并抑制秋水仙碱连接处的聚集。 它对癌细胞有选择性，包​​括耐药癌细胞。

Tartaric acid disodium dihydrate (Disodium L-(＋)-Tartrate Dihydrate) 常用来制作分子生物学和细胞培养中的缓冲液,。Tartaric acid disodium dihydrate 是酸性磷酸酶抑制剂, 可增加秋水仙碱结合 tubulin1的概率。

Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2 M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。

Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点，抑制tubulin聚合，进而促进有丝分裂阻断和apoptosis。

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.

LP-261 是一种新型的微管蛋白靶向抗癌剂，可与微管蛋白上的秋水仙碱位点结合，诱导 G2 M 期阻滞，其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长，可用于癌症研究。

Tubulin polymerization-IN-45 是针对微管蛋白的靶向抑制剂，通过与微管蛋白秋水仙碱结合位点相结合，能够诱导肝细胞癌细胞 (HCC) 发生细胞凋亡 (apoptosis)。

MY-875 is a potent microtubulin polymerization inhibitor that competes at colchicine binding sites, exhibiting an IC50 value of 0.92 μM. It effectively suppresses microtubulin polymerization, exerting its inhibitory effect. Additionally, MY-875 exerts its biological impact by activating the Hippo pathway, inducing apoptosis, and displaying commendable anticancer activity [1].

Tubulin polymerization-IN-39，一种以IC50为4.9μM抑制微管蛋白聚合，通过占据秋水仙碱结合位点来实现其作用。此外，Tubulin polymerization-IN-39能有效抑制癌细胞增殖。