ptu

Rosolutamide (ALZ-003) 是一种姜黄素类似物，一种具有口服活性 Nrf1 和 Nrf2 激活剂。Rosolutamide 可调节氧化稳态，改善线粒体功能并促进自噬，减少突变蛋白聚集，并降低细胞内/线粒体活性氧 (ROS) 水平，可用于研究脊髓小脑性共济失调和亨廷顿病等神经退行性疾病。调节氧化稳态。

Propylthiouracil (6-n-Propylthiouracil) 是一种甲状腺过氧化物酶抑制剂，也是一种5'-脱碘酶抑制剂。

D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can prevent the release of insulin and the utilization of carbohydrates in rats.

PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。

D-Sedoheptulose 7-phosphate is a common precursor of heptaic acid (group III) and the heptasaccharide of hygromycin B (group IV). This compound can be converted to NDP-heptose via similar biosynthetic pathways present in these substances.

Paracetamol Mercapturate is a metabolite of Acetaminophen. It can also be used in the biological study of urinary antihypertensive drugs.

Clofibrate mercapturate is a urinary metabolite of clofibrate.

Paracetamol mercapturate is a deuterated metabolite of acetaminophen.

Pentachlorophenylmercapturic acid is a bioactive chemical.

Pentylmercapturic acid is a bioactive chemical.

S-Allylmercapturic Acid (N-Acetyl-S-allyl-L-cysteine) 是存在于黑蒜中的 S-allyl-L-cysteine 代谢物，具有潜在的抗痛风作用，抑制 CYP2D6 和 CYP 催化的反应。

Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.

Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples.

D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway. [1] [2] In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate . D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics. [3]

BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。

S-Phenylmercapturic acid是苯的一种代谢物，可用作苯暴露的生物标志物。

Naptumomab (ABR-217620) 是一种由抗 5T4 癌胚抗原的 Fab 片段与改良型葡萄球菌肠毒素 A (SEA/E-120) 组成的肿瘤靶向超抗原 (TTS) 融合蛋白。该产物通过 Fab 段特异性识别多种实体瘤表面表达的 5T4 蛋白，并利用超抗原成分强效激活 T 细胞（主要通过与 TCR Vβ 链结合），诱导 T 细胞介导的细胞毒性作用来杀伤肿瘤细胞。它能绕过主要组织相容性复合体 (MHC) 限制，直接招募并激活大量效应 T 细胞进入肿瘤微环境。

Naptumomab estafenatox (ABR-217620) 是肿瘤靶向超抗原 (TTS)，它是一种融合蛋白，由抗5T4抗体和SEA/E-120超抗原组成。Naptumomab estafenatox 可用于肺癌的研究。

Zaptuzumab (AD5-10) 是一种人源化单克隆抗体，针对死亡受体 5 (DR5) 展现出高度选择性和结合亲和力。Zaptuzumab 通过caspase介导的凋亡 (apoptosis) 和自噬性细胞死亡 (ACD) 有效地诱导癌细胞死亡，还可以激活抗体依赖的细胞介导的细胞毒性作用 (ADCC) 和补体依赖的细胞毒性作用 (CDC)。此外，它能促进活性氧 (ROS) 产生并降低 谷胱甘肽 (GSH) 水平。在多种异种移植小鼠肿瘤模型中，Zaptuzumab 显示出显著的抑制肿瘤生长的效果，并且具有良好的安全性。

Sedoheptulose anhydride is a natural product.

D-altrofurano-heptulose-3 (alpha-D-Altro-3-heptulofuranose) 从猕猴桃 (Rupr. & Maxim.) Maxim., 猕猴桃科的根茎中分离得到。

Methyl (methyl 3-deoxy-D-arabino-heptulopyranosid)onate-7-phosphate 是用于糖生物学研究的生化试剂。糖生物学研究糖的结构、合成、生物学及进化，涵盖碳水化合物化学、聚糖酶学、蛋白质与聚糖的识别，以及聚糖在生物系统中的功能。该领域与基础研究、生物医学和生物技术密切相关。

Dicyclohexylammonium 3-hydroxy-1-methylpropylmercapturic acid 是巴豆醛（Crotonaldehyde）的代谢产物。巴豆醛是一种有机醛，广泛用于合成塑料、药物和香料。

CCB02 是选择性的 CPAP-tubulin 相互作用抑制剂。CCB02能够与 tubulin 结合，竞争 β-tubulin 的 CPAP 结合位点，IC50 值为 689 nM，显示出高效的抗肿瘤活性。CCB02 对其他的蛋白没有抑制作用，包括中心体、细胞周期相关蛋白，对 Aurora A，Plk1，Plk2，CDK2 和 CHK1 的磷酸化状态也无作用。