sufu

Nomegestrol acetate 是一种孕酮受体的完全激动剂，是一种高选择性孕激素。

Sufugolix (TAK-013) 是一种高效的、有口服活性的黄体激素释放激素(LHRH) 受体拮抗剂(IC50:0.1 nM)。

Antibacterialagent 189 (compound 3a) 是一种有效的抗菌剂。它对目标 OMPA/exo-1,3-β-葡聚糖酶蛋白展示了高结合能，并对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、枯草芽孢杆菌、白色念珠菌和黄曲菌具有显著的抗菌活性。此外，Antibacterialagent 189 对目标 SMO 和 SUFU/GLI-1 蛋白也表现出较高的结合能。

MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low µM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo.