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Anti-Sting Polyclonal Antibody

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产品编号 TMAB-01790

别名 TMEM173, sting, Stimulator of interferon genes protein, Mediator of IRF3 activation

Anti-Sting Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Sting。Anti-Sting Polyclonal Antibody 可用于 WB。

Anti-Sting Polyclonal Antibody

Anti-Sting Polyclonal Antibody

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产品编号 TMAB-01790 别名 TMEM173, sting, Stimulator of interferon genes protein, Mediator of IRF3 activation

Anti-Sting Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Sting。Anti-Sting Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-Sting Polyclonal Antibody is a Rabbit antibody targeting Sting. Anti-Sting Polyclonal Antibody can be used in WB.
别名TMEM173, sting, Stimulator of interferon genes protein, Mediator of IRF3 activation
Ig Type
IgG
交叉反应
Mouse,Rat (predicted:Human)
验证活性
Sample:
Lane 1: Mouse Lung tissue lysates
Lane 2: Mouse Uterus tissue lysates
Lane 3: Mouse Thymus tissue lysates
Lane 4: Mouse Large intestine tissue lysates
Lane 5: Rat Lung tissue lysates
Lane 6: Rat Uterus tissue lysates
Lane 7: Rat Thymus tissue lysates
Lane 8: Rat Large intestine tissue lysates
Primary: Anti-STING1 (TMAB-01790) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kDa
Observed band size: 38 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane. Mitochondrion outer membrane. Cell membrane. Cytoplasm > perinuclear region. In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.
组织特异性Ubiquitously expressed.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
抗原信息
免疫原
KLH conjugated synthetic peptide: human STING1
抗原种属
Human
基因名称
STING1
基因ID
蛋白名称
Stimulator of interferon genes protein
Uniprot ID
研究领域
NFkB pathway,NFkB pathway,Antiviral Signaling,Interferons,Transmembrane
功能
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
化学信息
分子量Theoretical: 42 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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