Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively).
Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性,IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分,可改善小鼠内源性性激素的平衡,提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性,提高性激素的生物转化效率,提高生殖能力。Lepidiline A 具有抗癌活性。
1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy.
α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors. It is a potent agonist specifically targeting P2X1 and P2X3 receptors while exerting negligible activity on P2X2, P2X4, P2X5, P2X6, and P2X7 receptors.
Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent.