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抑制剂&激动剂
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TargetMol产品目录中 "liver toxicity"的结果
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  • 抑制剂&激动剂
    32
    TargetMol | Inhibitors_Agonists
  • 化合物库
    1
    TargetMol | Compound_Libraries
  • 重组蛋白
    1
    TargetMol | Recombinant_Protein
  • 多肽产品
    1
    TargetMol | Peptide_Products
  • 天然产物
    7
    TargetMol | Natural_Products
  • 同位素
    1
    TargetMol | Isotope_Products
  • 疾病造模
    1
    TargetMol | Disease_Modeling_Products
  • 分子与细胞研究
    2
    TargetMol | Inhibitors_Agonists
  • Doxylamine succinate
    琥珀酸多西拉敏, Decapryn
    T1115562-10-7
    Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。
    • ¥ 127
    In stock
    规格
    数量
    TargetMol | Citations 客户已引用
  • S-(5'-Adenosyl)-L-methionine tosylate
    S-腺苷蛋氨酸对甲苯磺酸盐, SAMe, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt
    T444752248-03-0
    S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。
    • ¥ 260
    In stock
    规格
    数量
    TargetMol | Citations 客户已引用
  • CWP232228
    T109041144044-02-9
    CWP232228 是一种高效的、选择性的Wnt β-catenin 信号通路抑制剂,在细胞核中,拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长,抑制肿瘤的形成和转移,且没有毒性。
    • ¥ 1090
    In stock
    规格
    数量
  • Octachlorodibenzo-p-dioxin
    OCDD
    T2033133268-87-9
    Octachlorodibenzo-p-dioxin (OCDD) 是一种环境污染物,但没有急性给药毒性。在大鼠体内,Octachlorodibenzo-p-dioxin 通过静脉注射 (50 μg kg i.v.) 或口服 (50-5000 μg kg p.o.) 的全身消除半衰期为 3-5 个月,在低剂量的多次暴露后会在肝脏和脂肪组织中累积和浓缩。重复给药后,Octachlorodibenzo-p-dioxin 会导致7-乙氧基异噻唑啉-O-脱乙基酶 (7-ethoxyresorufin-O-deethylase, 7-EROD) 活性增加,以及总细胞色素P-450水平升高。
    • 待询
    10-14周
    规格
    数量
  • AChE/BuChE-IN-6
    T204119
    AChE BuChE-IN-6 (Compound 11f) 是一种AChE和BuChE的抑制剂,其IC50分别为1.24和1.85 μg mL。同时,AChE BuChE-IN-6 展现出卓越的DPPH自由基清除活性 (IC50=3.15 μg mL)。体内毒性研究显示,该化合物在长期给药后,血液及生化指标与对照组无显著差异,且肝脏和肾脏组织无异常,表明具有良好安全性。AChE BuChE-IN-6 在阿尔兹海默症的研究中具有潜力。
    • 待询
    规格
    数量
  • IPH10
    T205522
    IPH10 是一种抗癌剂,在体内表现出显著的抗肿瘤作用,且不具有肝、肾毒性。IPH10 可明显增加肿瘤细胞内ROS含量,降低线粒体膜电位,从而诱导肿瘤细胞发生凋亡 (apoptosis)。
    • 待询
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  • Fluproquazone
    Tormosyl, 46-790, 46 790
    T2543140507-23-1
    Fluproquazone is a quinazolinone derivative with potent antipyretic, analgesic, and anti-inflammatory effects. However, it was withdrawn during development due to liver toxicity.
    • ¥ 11700
    6-8周
    规格
    数量
  • Aflatoxin G1-13C17
    Aflatoxin G1-13C17
    T355201217444-07-9
    Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase, NADH oxidase, α-glycerophosphate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Aliment.31(4-6)607-615(1977) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogsCancer Res.31(12)1936-1942(1971) 3.Bai, N.J., Pai, M.R., and Venkitasubramanian, T.A.Mitochondrial function in aflatoxin toxicityIndian J. Biochem. Biophys.14(4)347-349(1977)
    • 待询
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  • TFM
    T3763288-30-2
    TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formulations containing TFM have been used as lampricides in the control of larval sea lamprey populations. 1.Boogaard, M.A., Bills, T.D., and Johnson, D.A.Acute toxicity of TFM and a TFM/niclosamide mixture to selected species of fish, including lake sturgeon (Acipenser fulvescens) and mudpuppies (Necturus maculosus), in laboratory and field exposuresJ. Great Lakes Res.29(Suppl 1)529-541(2003) 2.Birceanu, O., McClelland, G.B., Wang, Y.S., et al.The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) uncouples mitochondrial oxidative phosphorylation in both sea lamprey (Petromyzon marinus) and TFM-tolerant rainbow trout (Oncorhynchus mykiss)Comp. Biochem. Physiol. C. Toxicol. Pharmacol.153(3)342-349(2011)
    • ¥ 812
    35日内发货
    规格
    数量
  • L-Cysteine-glutathione disulfide
    T3831213081-14-6
    L-Cysteine-glutathione disulfide 是治愈肺结核的潜在生物标志物,是哺乳动物细胞中普遍存在的物质,具有保肝作用,可用于研究乙酰氨基酚诱导的肝毒。
    • ¥ 1080
    35日内发货
    规格
    数量
  • β-Secretase Inhibitor I
    T392511818239-19-8
    β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity.
    • ¥ 10600
    6-8周
    规格
    数量
  • Ethyl trans-caffeate
    咖啡酸乙酯, 反式咖啡酸乙酯, Ethyl caffeate, Caffeic Acid Ethyl Ester
    T3S001366648-50-8
    Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。 它是一种有前途的天然化合物,未来在慢性肝病中的应用。它是一种有效的化学预防化合物,可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。 它强烈抑制 JB6 Cl41细胞的肿瘤转化,无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
    • ¥ 230
    待询
    规格
    数量
    TargetMol | Citations 客户已引用
  • S-Adenosyl-DL-Methionine
    S-腺苷蛋氨酸, S-ADENOSYL-L-METHIONINE, Ademetionine
    T411617176-17-9
    S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。
    • ¥ 522
    5日内发货
    规格
    数量
  • Glycerol
    甘油, Glycerin
    T477656-81-5
    Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分,广泛应用于食品工业中作为甜味剂和保湿剂以及药物制剂。此外,Glycerol 可用于聚丙烯酰胺凝胶电泳的样品制备和凝胶形成,并可用于诱导急性肾损伤模型。
    • ¥ 143
    In stock
    规格
    数量
  • NLRP3-IN-8
    T622212768650-56-0
    NLRP3-IN-8 (compound 27) 是具有口服活性的、与 NLRP3直接结合的 NLRP3炎性体抑制剂,对 IL-1β 的 IC50值为1.23 μM. NLRP3-IN-8 对肝微粒体具有良好的代谢稳定性 (t1 2= 138.63 min),几乎没有毒性 (against L02: IC50> 100 μM) 。
    • ¥ 10600
    10-14周
    规格
    数量
  • CYP2C1/CYP2C19-IN-2
    T63495
    CYP2C1 CYP2C19-IN-2 是无肝脏毒性和遗传毒性的CYP2C9 CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。
    • ¥ 10600
    10-14周
    规格
    数量
  • CYP2C9/CYP2C19-IN-1
    T63496
    CYP2C9 CYP2C19-IN-1 是无肝脏毒性和遗传毒性的CYP2C9 CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。
    • ¥ 10600
    10-14周
    规格
    数量
  • NU5455
    T642041257235-99-6
    NU5455 是一种选择性的、有效的、口服具有活力的 DNA-PKcs 抑制剂。NU5455 能够提高肝肿瘤异种移植物中局部释放的多柔比星的效果,且不引起任何不良反应。NU5455 能够提高肠胃外给药的拓扑异构酶抑制剂的功效和毒性。
    • ¥ 10600
    10-14周
    规格
    数量
  • APBC
    T69447324054-99-1
    APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1 PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-L1 knock-in B16F10-bearing mouse model without the induction of observable liver toxicity.
    • ¥ 10600
    6-8周
    规格
    数量
  • Nemorubicin HCL
    T71467108943-08-4
    Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases.
    • ¥ 10600
    1-2周
    规格
    数量
  • PI3K/mTOR Inhibitor-12
    T723742891692-83-2
    PI3K mTOR Inhibitor-12为口服有效且选择性的PI3K mTOR抑制剂,对PI3Kα和mTOR的IC50分别为0.06 nM及3.12 nM,表现出抗肿瘤活性且肝毒性较低。
    • ¥ 11700
    8-10周
    规格
    数量
  • Cisd2 agonist 2
    T827192916371-59-8
    Cisd2 agonist 2(compound 6)是Cisd2激活剂,具有191 nM的EC50值,其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠(杂合子肝细胞特异性Cisd2敲除)中,Cisd2 agonist 2未显示出显著的体内毒性。
    • 待询
    8-10周
    规格
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  • Bemfivastatin hemicalcium
    PPD 10558 hemicalcium
    T82900805241-64-9
    Bemfivastatin (PPD 10558) hemicalcium 作为口服HMG-CoA还原酶抑制剂,具备有效的降脂作用并能增强肝脏提取活性。该化合物的未观察到不良反应水平(NOAEL)在大鼠发育毒性研究中超过320 mg kg d,在家兔母体毒性及发育毒性研究中分别超过12.5 mg kg d和25 mg kg d。Bemfivastatin hemicalcium 适用于对他汀类药物不耐受且患有他汀相关性高胆固醇血症性肌痛的研究。
    • 待询
    8-10周
    规格
    数量
  • Anti-infective agent 9
    T85685758689-17-7
    Anti-infective agent 9(compound 1)作为恶性疟原虫的有效抑制剂(IC50=600 nM),能有效降低疟原虫中的丙酮酸水平和TCA循环活性。该化合物显示出良好的代谢稳定性,且对人类肝细胞的毒性较低。进一步研究表明,Anti-infective agent 9抑制恶性疟原虫生长的作用机制并非通过1-脱氧-d-木酮糖-5-磷酸合酶(DXPS)。
    • 待询
    10-14周
    规格
    数量