c-Met/HGFR

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing.

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure
T3512	S49076 HCl 化合物S49076 HCl	1265966-31-1
T3512	S49076 HCl (S-49076 Hydrochloride) 是 MET、AXL/MER 和 FGFR1/2/3 的有效抑制剂。S49076 HCl 在体外和体内有效阻断 MET、AXL 和 FGFR 的细胞磷酸化并抑制下游信号传导。在细胞模型中，S49076 HCl (S-49076 Hydrochloride...
T78206	Canlitinib 化合物 Canlitinib	2222730-78-9	98%
T78206	Canlitinib是一种氨酸激酶抑制剂，具有在癌症研究中应用的潜力。
T78843	MET/PDGFRA-IN-1 化合物 MET/PDGFRA-IN-1		98%
T78843	MET/PDGFRA-IN-1 (compound 8c) 作为MET和PDGFRA蛋白的抑制剂，以36 μM对MET的IC50值显示活性。该化合物能够抑制MET磷酸化并触发细胞凋亡(apoptosis)。此外，MET/PDGFRA-IN-1有效抑止了多种MET阳性细胞系的增殖，包括AsPc-1、EBC-1、MKN-45...
T78844	MET/PDGFRA-IN-2 化合物 MET/PDGFRA-IN-2		98%
T78844	MET/PDGFRA-IN-2（化合物8h）是一种针对MET和PDGFRA蛋白的抑制剂，具有诱导细胞凋亡（apoptosis）的功能。该化合物能有效抑制多种MET表达细胞系的增殖，包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562细胞，其IC50分别为9.7、6.1、12.0、11.5...
T78934	C-Met-IN-18 化合物 c-Met-IN-18		98%
T78934	c-Met-IN-18 是对 WT（Wild Type）和 D1228V 变异型 c-MET 具有 ATP 竞争性抑制作用的 III 型 c-MET 抑制剂。该化合物对 WT/D1228V 显示出不同程度的抑制活性，其 IC50 值分别为 0.013/0.20μM。c-Met-IN-18 主要用于研究 c-MET 驱动的...
T79142	C-Met-IN-17 化合物 c-Met-IN-17		98%
T79142	c-Met-IN-17，一种高效c-Met激酶抑制剂，IC50为0.031μM，适用于癌症治疗研究。
T79466	Antitumor agent-111 化合物 Antitumor agent-111		98%
T79466	Antitumor agent-111（compound 46）是一款c-Met激酶抑制剂，IC50为46 nM，显示出抗肿瘤和抗增殖特性。该化合物能够导致细胞周期在G0/G1期停滞，并诱发细胞凋亡（apoptosis）。
T79612	Tyrosine kinase-IN-6 化合物 Tyrosine kinase-IN-6	2377507-01-0	98%
T79612	Tyrosine kinase-IN-6为RON剪接变异体抑制剂，有效展现抗癌及抗肿瘤活性。
T79715	C-Met-IN-19 化合物 c-Met-IN-19		98%
T79715	c-Met-IN-19（Compound 21j）作为c-Met抑制剂，呈现出对A549、HT-29、SGC-7901、MDA-MB-231细胞系的细胞毒效应，其IC50分别为0.25、0.36、0.98、0.76 μM，并具有较高的抑制活性（IC50: 1.99 nM）。
T80521	Caveolin-1 (82-101) amide (human, mouse, rat) 化合物 Caveolin-1 (82-101) amide (human, mouse, rat)	2757108-69-1	98%
T80521	Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) 是抑制酪氨酸激酶的肽，可逆转多器官衰老相关的有害变化。
T82608	Davutamig 化合物 Davutamig	2648058-48-2	98%	Davutamig
T82608	Davutamig (REGN-5093)为人源化免疫球蛋白G4-kappa型抗MET单克隆抗体，特异性结合MET的两个独立非重叠表位，具有抗肿瘤活性。			Davutamig
T83433	1D228 化合物 1D228		98%
T83433	1D228为c-Met/TRK抑制剂，显示出抗肿瘤活性。该化合物通过抑制细胞周期蛋白D1，诱导G0/G1停滞，进而抑制癌细胞的增殖和迁移。该化合物适用于胃肿瘤、肝肿瘤和血管肿瘤研究领域。
T12417	PF-04217903 methanesulfonate 化合物 T12417	956906-93-7	98%
T12417	PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T10653	C-met-IN-1 化合物 T10653	2084836-84-8	98%
T10653	c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.
T17184	Tyrosine kinase inhibitor 化合物Tyrosine kinase inhibitor	1021950-26-4	98%
T17184	Tyrosine kinase inhibitor 是酪氨酸激酶的有效抑制剂。
T15383	Glesatinib hydrochloride 化合物 T15383	1123838-51-6	98%
T15383	Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P...
T10654	C-Met-IN-2 化合物 T10654	1635406-73-3	98%
T10654	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.
T12418	PF-04217903 phenolsulfonate 化合物 T12418	1159490-85-3	98%
T12418	PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T15384	Glesatinib 化合物 T15384	936694-12-1	98%
T15384	Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multi...
TN4474	Macrocarpal B 化合物 TN4474	142698-60-0	98%
TN4474	The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.